Evidence map›Paper›PMID 39738887›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Impact of radiotherapy-related late toxicities of skin and soft tissue in the neck on quality of life in head and neck cancer patients: a multi-institutional observational study in Japan.

Takuya Higashino, Masashi Wakabayashi, Sadamoto Zenda, Yoshichika Yasunaga, Jun Araki, Takashi Mukaigawa, Tetsuro Onitsuka, Masahiro Nakagawa, Atsumori Hamahata, Keigo Narita and 14 more

Abstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Takuya HigashinoDepartment of Plastic and Reconstructive Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. takhigas@east.ncc.go.jp.ORCID http://orcid.org/0000-0002-8153-1836
Masashi WakabayashiBiostatistics Division, Center for Research Administration and Support, National Cancer Center Hospital East, Kashiwa, Japan.
Sadamoto ZendaDepartment of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Yoshichika YasunagaDivision of Plastic and Reconstructive Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Jun ArakiDivision of Plastic and Reconstructive Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Takashi MukaigawaDivision of Head and Neck Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Tetsuro OnitsukaDepartment of Head and Neck Surgery, Mishima Central Hospital, Shizuoka, Japan.
Masahiro NakagawaDepartment of Plastic Reconstructive Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
Atsumori HamahataDepartment of Plastic and Reconstructive Surgery, Saitama Cancer Center, Saitama, Japan.
Keigo NaritaDepartment of Plastic and Reconstructive Surgery, Kyorin University, Tokyo, Japan.
Masaki ArikawaDepartment of Plastic and Reconstructive Surgery, National Cancer Center Hospital, Tokyo, Japan.
Keisuke TakanariDepartment of Plastic and Reconstructive Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
Hideki KadotaDepartment of Plastic and Reconstructive Surgery, Kyushu University Hospital, Fukuoka, Japan.
Daisuke YanagisawaDepartment of Plastic and Reconstructive Surgery, Shinshu University, Matsumoto, Japan.
Kentaro TanakaDepartment of Plastic and Reconstructive Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroshi MatsumotoDepartment of Plastic and Reconstructive Surgery, Okayama University, Okayama, Japan.
Yoshihiro KimataDepartment of Plastic and Reconstructive Surgery, Okayama University, Okayama, Japan.
Shimpei MiyamotoDepartment of Plastic and Reconstructive Surgery, The University of Tokyo, Tokyo, Japan.
Minoru SakurabaDepartment of Plastic and Reconstructive Surgery, Iwate Medical University, Morioka, Japan.
Kenichiro KawaiDepartment of Plastic Surgery, Hyogo Medical University, Hyogo, Japan.
Yasunobu TeraoDepartment of Plastic and Reconstructive Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Ikuo HyodoDepartment of Plastic and Reconstructive Surgery, University of Occupational and Environmental Health, Fukuoka, Japan.
Katsuhiro IshidaDepartment of Plastic and Reconstructive Surgery, Jikei University School of Medicine, Tokyo, Japan.
Kotaro YoshimuraDepartment of Plastic Surgery, Jichi Medical University, Tochigi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis multi-institutional observational study aimed to assess the incidence, severity, and impact of radiotherapy-related late toxicities of the cervical skin and soft tissue in head and neck cancer patients. We also explored patient interest in fat grafting as a potential treatment for skin and soft tissue sequelae.

methodsThis study was conducted across 19 institutions in Japan. The study involved head and neck cancer patients who received ≥ 60 Gy of cervical radiotherapy concomitant with a history of neck dissection and were free of cancer recurrence ≥ 3 years after the final treatment. Consenting outpatients completed a self-administered questionnaire to collect data on symptom severity and the attending outpatient physicians reported data on demographics and treatments in a case report form.

resultsA total of 222 patients were enrolled. The incidence proportion of late cervical skin and soft tissue toxicities was 96%, with 32% of patients reporting their symptoms as severe, and 69% of patients reporting an impact on quality of life (QOL). An interest in or consideration of fat grafting was reported by 34% of patients, with a greater desire among those with severe symptoms.

conclusionThis study elucidated the incidence, severity, and life impact of late toxicities affecting the cervical skin and soft tissue after radiotherapy for head and neck cancer. These late toxicities were highly prevalent and significantly impacted QOL. There is a substantial demand for new treatments, such as fat grafting, to address these complications and enhance the QOL for survivors of head and neck cancer.

Indexed as

Head and Neck NeoplasmsQuality of LifeAdultAgedAged, 80 and overFemaleHumansIncidenceJapanMaleMiddle AgedRadiation InjuriesSeverity of Illness IndexSkinSurveys and QuestionnairesHead and neck neoplasmsMesenchymal stem cell transplantationMorbidityNeck dissectionQuality of lifeRadiotherapy

Identifiers

PMID39738887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.