Trial reportLa Radiologia medica2025
Lean body weight-based contrast injection protocol in liver CT: optimization of contrast medium dose.
Trial report in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Greening computed tomography: a position paper on environmentally responsible imaging practice from the computed tomography subspecialty section of the Italian society of radiology.La Radiologia medica · 2026Article
- Abbreviated non-contrast magnetic resonance enterography for Crohn's disease: a reliability study.La Radiologia medica · 2026Article
- Iodinated Contrast Media Dose Protocols for Computed Tomography Investigations of the Abdomen: A Systematic Review and Meta-Analysis.Journal of imaging · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate liver enhancement and image quality of abdominal CECT examinations acquired with multiple LBW-based contrast medium injection protocols. MATERIAL &
methodsOne hundred fifty patients who underwent a clinically indicated CECT examination were prospectively and randomly assigned to one of the following contrast medium injection protocol groups: A, 700 mg iodine(I)/kg of LBW; B, 650 mgI/kg of LBW; and C, 600 mgI/kg of LBW. Liver signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and magnitude of contrast enhancement (ΔHU) were calculated. Subjective image quality was assessed with 5-point Likert scale.
resultsThe final population included 145 patients (64 females), with 50, 48, and 47 in group A, B, and C, respectively. Group A showed significantly higher SNR, CNR and ΔHU than group B (p = .018, p = .004, and p = .031, respectively) and group C (p = .024, p = .043, and p = .004). Group B had similar SNR, CNR, and ΔHU to group C (all p = 1). ΔHU was < 50 HU in 2, 7, and 11 patients in group A (48.2 ± 0.1), B (43.7 ± 5), and C (44.4 ± 5), respectively. Group A achieved the highest scores in terms of overall image quality, artifacts, and diagnostic confidence (both scores: 4; IQRs: 4-5) compared to group B (both scores: 3; IQRs: 3-5; p ≥ .037) and group C (overall image quality score: 3; IQR: 2-5; p = .011. Artifact and diagnostic confidence score: 3; IQR: 1-4; p ≥ .009).
conclusionsA dosage of 700 mgI/kg of LBW yields optimal liver enhancement and grants higher image quality compared to lower contrast medium dosages.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.