Evidence map›Paper›PMID 39738859›Full record

ReviewInternational urology and nephrology2025

Vitamin D: an important treatment for secondary hyperparathyroidism in chronic kidney disease?

Jie Yu, Yulu Li, Bin Zhu, Jianqin Shen, Liying Miao

Abstract readReview
In one paragraph

Review in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jie YuDepartment of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Yulu LiDepartment of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Bin ZhuDepartment of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Jianqin ShenDepartment of Blood Purification Center, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Liying MiaoDepartment of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China. lymiao@sina.com.

Funding

Changzhou Sci&Tech CJ.20230054the program of major science and technology project of changzhou health commission ZD.202101
6 · The paper itself

Abstract

Secondary hyperparathyroidism (SHPT) is one of the most common complications of chronic kidney disease (CKD). Vitamin D levels begin to decrease in the early stages of CKD, and these vitamin D-related changes play a central role in the occurrence and development of SHPT. Vitamin D-based drugs, which inhibit parathyroid hormone secretion either directly or indirectly, are commonly used to treat SHPT. However, vitamin D-based drugs can also lead to a dysregulated balance between serum calcium and phosphorus, as well as other adverse reactions. Over the past several decades, researchers have conducted in-depth studies on the pathogenesis of SHPT, developed new vitamin D-based drugs, and explored combinatory methods to improve treatment efficacy for the disease. Here, we review vitamin D metabolism, the diagnosis of vitamin D deficiency in patients with CKD, the pathogenesis of SHPT, the pharmacological effects of vitamin D drugs, and the benefits and side effects of using vitamin D to treat SHPT.

Indexed as

Hyperparathyroidism, SecondaryRenal Insufficiency, ChronicVitamin DVitamin D DeficiencyVitaminsHumansVitamin DVitaminsChronic kidney diseaseComplicationMechanismSecondary hyperparathyroidismTreatmentVitamin D

Identifiers

PMID39738859
PMCPMC12049386

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.