ArticleClinical rheumatology2025
Causal association between bone mineral density and the risk of joint replacement in patients with osteoarthritis: a Mendelian randomization study.
Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Unraveling the brain-joint axis: genetic, transcriptomic, and cohort insights from neuroticism to osteoarthritis.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Population-based studies have been inconsistent in terms of the relationship between bone mineral density (BMD) and the progression of osteoarthritis. This study aimed to evaluate the causal relationship between BMD and the risk of joint replacement in patients with osteoarthritis. We performed a two-sample Mendelian randomization (MR) analysis to determine the association of BMD of the total body, femoral neck, and lumbar spine with the risk of hip and knee replacements. Inverse variance weighting (IVW) was used as the main analysis method. Heterogeneity and horizontal pleiotropy were checked. Multivariable MR analysis was performed by adjusting for hip/knee pain, body mass index (BMI), estrogen levels, BMI-based sex hormone-binding globulin (SHBG) levels, and physical activity. BMD of the total body and the lumbar spine were significantly associated with higher risks of both knee (IVW odds ratios (ORs) = 1.08-1.10, p = 4.62E-03) and hip replacements (IVW ORs = 1.19-1.37, P = 3.23E-09). Femoral neck BMD was significantly associated with the risk of hip but not knee replacement (IVW OR = 1.27, 95% confidence interval 1.13 to 1.43, p = 9.15E-05). Multivariable MR analyses produced similar results compared to the univariable analyses. No evidence of heterogeneity and horizontal pleiotropy were found, except that there was heterogeneity in the association between total body BMD and the risk of knee replacement. BMD is significantly associated with an increased risk of both knee and hip replacement, and the association is stronger for hip replacement. These findings suggest a causal relationship between BMD and the progression of osteoarthritis. Key Points • BMD is associated with an increased risk of hip and knee joint replacement. • BMD was more strongly associated with hip replacement risk.
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Registered trials
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