ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025
Cervicothoracic volumetric bone mineral density assessed by opportunistic QCT may be a reliable marker for osteoporosis in adults.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- AI for Opportunistic Identification of BMD and Bone Microarchitecture: A Narrative Review.Calcified tissue international · 2026Review
- Proportions of fall-related and insufficiency-related vertebral fractures among hospitalized older patients.Archives of osteoporosis · 2026Article
- Knee-specific bone quality assessment for cementless total knee arthroplasty candidate selection: a narrative review.Knee surgery & related research · 2026Review
- Vertebral-level discrimination of incidental vertebral fractures using volumetric BMD, texture features, and finite element-derived fracture load: an exploratory study.Skeletal radiology · 2026Article
- Anterior-posterior difference of MRI-based cervical vertebral bone quality score independently predicts overloaded vertebral body wedge deformity after anterior cervical discectomy and fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Artificial Intelligence in Rheumatology: From Algorithms to Clinical Impact in Osteoporosis and Chronic Inflammatory Rheumatic Diseases.Journal of clinical medicine · 2026Article
- Central Bone Mineral Density Is Not a Reliable Surrogate for Assessing Suitable Bone Strength for Cementless Total Knee Arthroplasty.Journal of clinical medicine · 2025Article
- Changes in scanographic bone mineral density in melanoma patients treated with immunotherapy: a new irAE from real-life data.Scientific reports · 2025Article
- Simulated low-dose multi-detector computed tomography: spatial effects on surrogate parameters of bone strength at the proximal femur.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Thoracic vertebral bone mineral density measured by quantitative computed tomography is associated with fracture risk in lung cancer screening populations: a prospective cohort study.Frontiers in endocrinology · 2025Article
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15 authors.
Funding
Abstract
This study aimed to validate the correlation between volumetric bone mineral density in the cervicothoracic and lumbar spine using measurements from opportunistic CT scans. The bone density assessment proved feasible, allowing us to propose optimal cut-off values for diagnosing osteoporosis and predicting vertebral fractures in the cervical and thoracic spine.
objectivesTo investigate the performance of cervicothoracic volumetric bone mineral density (vBMD), obtained through opportunistic quantitative computed tomography (QCT), in discriminating patients with/without osteoporosis and with/without vertebral fractures (VFs), using lumbar vBMD as the reference.
methodsThree hundred twenty-five patients (65.3 ± 19.2 years, 140 women) with routine non-contrast or contrast-enhanced multi-detector CT (MDCT) scans were included. Trabecular vBMD was automatically extracted from each vertebra using a convolutional neural network (CNN)-based framework (SpineQ software v1.0) with asynchronous calibration and contrast phase correction. The correlations of vBMD between each vertebra spanning C2-T12 and the averaged lumbar spine (L1-L3, or L4 and L5) vBMD values were analyzed, considering fracture status and degeneration. Vertebra-specific linear regression equations were used to approximate lumbar vBMD at the cervicothoracic spine.
resultsCervicothoracic vBMD correlated well with lumbar vBMD (r = 0.79), with significant improvement after excluding degenerated vertebrae (p < 0.05; r = 0.89), except for C7-T3 and T9. Cervical (AUC = 0.94) and thoracic vBMD (AUC = 0.97) showed strong discriminatory ability for osteoporosis (vBMD < 80 mg/cm
conclusionCervicothoracic vBMD may allow for determination of osteoporosis and prediction of VFs.
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