Evidence map›Paper›PMID 39738813›Full record

ArticleEJNMMI radiopharmacy and chemistry2024

Optimized chelator and nanoparticle strategies for high-activity

Emanuel Sporer, Claire Deville, Natan J W Straathof, Linda M Bruun, Ulli Köster, Mikael Jensen, Thomas L Andresen, Paul J Kempen, Jonas R Henriksen, Andreas I Jensen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emanuel SporerThe Hevesy Laboratory, DTU Health Technology, Frederiksborgvej 399, 4000, Roskilde, Denmark.ORCID http://orcid.org/0009-0006-2514-255X
Claire DevilleThe Hevesy Laboratory, DTU Health Technology, Frederiksborgvej 399, 4000, Roskilde, Denmark.ORCID http://orcid.org/0000-0002-5007-912X
Natan J W StraathofThe Hevesy Laboratory, DTU Health Technology, Frederiksborgvej 399, 4000, Roskilde, Denmark.ORCID http://orcid.org/0000-0003-0293-1530
Linda M BruunSection for Cell and Drug Technologies, DTU Health Technology, Produktionstorvet Bld. 423, 2800, Lyngby, Denmark.ORCID http://orcid.org/0000-0002-2617-9606
Ulli KösterInstitut Laue-Langevin, 71 Avenue Des Martyrs, 38042, Grenoble, France.ORCID http://orcid.org/0000-0001-5701-3249
Mikael JensenThe Hevesy Laboratory, DTU Health Technology, Frederiksborgvej 399, 4000, Roskilde, Denmark.ORCID http://orcid.org/0000-0002-9109-2187
Thomas L AndresenThe Hevesy Laboratory, DTU Health Technology, Frederiksborgvej 399, 4000, Roskilde, Denmark.ORCID http://orcid.org/0000-0002-1048-127X
Paul J KempenNational Centre for Nano Fabrication and Characterization, DTU Nanolab, Ørsteds Plads 347, 2800, Lyngby, Denmark.ORCID http://orcid.org/0000-0003-2179-2257
Jonas R HenriksenSection for Cell and Drug Technologies, DTU Health Technology, Produktionstorvet Bld. 423, 2800, Lyngby, Denmark.ORCID http://orcid.org/0000-0001-9154-6639
Andreas I JensenThe Hevesy Laboratory, DTU Health Technology, Frederiksborgvej 399, 4000, Roskilde, Denmark. atije@dtu.dk.ORCID http://orcid.org/0000-0002-9085-8603

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrachytherapy (BT) is routinely used in the treatment of various cancers. Current BT relies on the placement of large sources of radioactivity at the tumor site, requiring applicators that may cause local traumas and lesions. Further, they suffer from inflexibility in where they can be placed and some sources reside permanently in the body, causing potential long-term discomfort. These issues can be circumvented through injectable sources, prepared as biodegradable materials containing radionuclides that form solid seeds after administration. The level of radioactivity contained in such seeds must be sufficient to achieve substantial local irradiation. In this report, we investigate two different strategies for biodegradable BT seeds.

resultsThe first strategy entails injectable seeds based on

conclusionBoth strategies for forming injectable BT seeds containing high

Indexed as

Auger radiotherapyBiodegradable gelsBrachytherapyGold nanoparticlesPalladium-103Radiochemistry

Identifiers

PMID39738813
PMCPMC11685337

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.