Evidence map›Paper›PMID 39738736›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2024

Multitarget Peptides Released by In Vitro Static Gastrointestinal Digestion of an Amaranth Protein Beverage.

S E Suárez, A Quiroga, A C Sabbione, M Rodríguez, A E Nardo, J Jardin, A Scilingo, V Tironi, F Speroni, M C Añón

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

S E SuárezLaboratorio de Investigación, Desarrollo e Innovación de Proteínas Alimentarias (LIDiPA), Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, CONICET-CIC-UNLP), Street 47 and 116, La Plata, Buenos Aires, Argentina.
A QuirogaLaboratorio de Investigación, Desarrollo e Innovación de Proteínas Alimentarias (LIDiPA), Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, CONICET-CIC-UNLP), Street 47 and 116, La Plata, Buenos Aires, Argentina.
A C SabbioneLaboratorio de Investigación, Desarrollo e Innovación de Proteínas Alimentarias (LIDiPA), Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, CONICET-CIC-UNLP), Street 47 and 116, La Plata, Buenos Aires, Argentina.
M RodríguezLaboratorio de Investigación, Desarrollo e Innovación de Proteínas Alimentarias (LIDiPA), Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, CONICET-CIC-UNLP), Street 47 and 116, La Plata, Buenos Aires, Argentina.
A E NardoLaboratorio de Investigación, Desarrollo e Innovación de Proteínas Alimentarias (LIDiPA), Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, CONICET-CIC-UNLP), Street 47 and 116, La Plata, Buenos Aires, Argentina.
J JardinINRAE, Institut AGRO, STLO, 35042, Rennes, France.
A ScilingoLaboratorio de Investigación, Desarrollo e Innovación de Proteínas Alimentarias (LIDiPA), Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, CONICET-CIC-UNLP), Street 47 and 116, La Plata, Buenos Aires, Argentina.
V TironiLaboratorio de Investigación, Desarrollo e Innovación de Proteínas Alimentarias (LIDiPA), Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, CONICET-CIC-UNLP), Street 47 and 116, La Plata, Buenos Aires, Argentina.
F SperoniLaboratorio de Investigación, Desarrollo e Innovación de Proteínas Alimentarias (LIDiPA), Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, CONICET-CIC-UNLP), Street 47 and 116, La Plata, Buenos Aires, Argentina.
M C AñónLaboratorio de Investigación, Desarrollo e Innovación de Proteínas Alimentarias (LIDiPA), Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, CONICET-CIC-UNLP), Street 47 and 116, La Plata, Buenos Aires, Argentina. mcacidca@gmail.com.

Funding

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación PICT 2016 N° 1537
6 · The paper itself

Abstract

Beverages formulated from alternative proteins, such as amaranth, are gaining attraction due to changes in human dietary patterns and environmental concerns like resource use and biodiversity loss. This study focuses on assessing the bioactive peptide release from an amaranth protein beverage. This beverage was subjected to a static simulated gastrointestinal digestion (SGD) protocol to evaluate its bioaccessibility and functional potential. The digests were analyzed for in vitro antihypertensive, antioxidant, and antithrombotic activities. Additionally, digested peptide sequences were identified via LC-MS/MS. The results showed that SGD significantly enhanced the release of bioactive peptides, leading to increased ACE inhibition, antioxidant capacity against ABTS + and AAPH-induced radicals, and antithrombotic effects in clotting assays. LC-MS/MS analysis identified 31 peptides in the digests, ranging from 9 to 21 amino acids, associated with various bioactivities. These findings highlight amaranth proteins potential as a source of functional peptides with health-promoting properties. Further research must be done to isolate and characterize specific peptides for potential therapeutic applications.

Indexed as

AmaranthusAntihypertensive AgentsAntioxidantsBeveragesDigestionPeptidesTandem Mass SpectrometryAngiotensin-Converting Enzyme InhibitorsChromatography, LiquidFibrinolytic AgentsGastrointestinal TractHumansPlant ProteinsAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsAntioxidantsFibrinolytic AgentsPeptidesPlant ProteinsAmaranthBeverageBioactive peptidesGastrointestinal digestion

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.