Evidence map›Paper›PMID 39738592›Full record

ArticleAnnals of hematology2025

Severe aplastic anemia with acquired X chromosome clonality as a sole abnormality.

Tim Jang, Rachel D Burnside, Joanna Chaffin, Robert Seifert, John W Hiemenz

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In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tim JangDepartment of Medicine, Division of Hematology/Oncology, University of Florida College of Medicine, Gainesville, FL, USA. Tim.Jang@medicine.ufl.edu.ORCID http://orcid.org/0000-0003-2783-8914
Rachel D BurnsideDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-0063-2281
Joanna ChaffinDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Robert SeifertDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-4404-8116
John W HiemenzDepartment of Medicine, Division of Hematology/Oncology, University of Florida College of Medicine, Gainesville, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case is a rare presentation of severe aplastic anemia in a 31-year-old male with acquired clonality of the X chromosome as the sole cytogenetic abnormality. This abnormality has not been reported to our knowledge, and the significance of this finding remains unclear. Comprehensive diagnostic workup included bone marrow biopsy, cytogenetic analysis, and Next-Generation sequencing, which revealed no tier I/II variants typically associated with clonal hematopoietic disorders. The patient was managed with triple immunosuppressive therapy pending hematopoietic stem cell transplant evaluation and workup. The clinical and genetic findings in this case are noteworthy for possible pre-malignant aberration, highlighting the need for further investigation into isolated chromosomal anomalies in aplastic anemia in the future.

Indexed as

Anemia, AplasticChromosomes, Human, XSex Chromosome AberrationsAdultHumansImmunosuppressive AgentsMaleImmunosuppressive AgentsAplastic anemia (AA)Chromosomal abnormalitiesClonal hematopoiesisGain of X chromosomeSevere aplastic anemia (SAA)

Identifiers

PMID39738592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.