ArticleScientific reports2024
Rapid microcystin-LR detection using antibody-based electrochemical biosensors with a simplified calibration curve approach.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Harmful algal blooms (HABs) can release cyanotoxins such as microcystins (MCs), especially, microcystin-leucine-arginine (MC-LR) which is one of the commonest and most toxic, into our water bodies and can lead to several acute or chronic diseases such as liver diseases and respiratory irritation in humans. There is an increasing need for rapid and simple detection of MC-LR in water bodies for early warning of HABs. In this study, we developed an innovative on-site screening electrochemical impedance spectroscopy (EIS) biosensor with a simplified calibration curve that can rapidly detect blooms for early action in similar water bodies. The novel aspect of this research is that various chemical cleaning procedures and surface modifications were evaluated to improve the antibody-embedded electrochemical sensor performance. In addition, a simplified calibration curve was constructed from different water samples to reduce the need for frequent recalibration in practical applications. In this study, two distinct commercially available screen-printed carbon electrodes (SPCEs) were modified as a cost-effective substrate for MC-LR biosensing with anti-MC-LR/MC-LR/cysteamine-coating. The study showed that an appropriate cleaning procedure might minimize the sensor performance difference after each electrode modification. The biosensor showed excellent sensitivity toward MC-LR detection in lake water samples with a limit of detection (LOD) of 0.34 ngL
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