Evidence map›Paper›PMID 39738448›Full record

ArticleScientific reports2024

Non-carcinogenic health risks of fluoride exposure in minors based on national surveillance in China, 2014 and 2018.

Liu Yang, Mang Li, Junrui Pei, Lijun Zhao, Wei Wei

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liu Yang *Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China.
Mang Li *Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China.
Junrui PeiCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. peijunrui@ems.hrbmu.edu.cn.
Lijun ZhaoCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. zhaolijun1012@163.com.
Wei WeiCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. hrbmuww@163.com.

Funding

the National Key R&D Program of China 2022YFC2503000the National Natural Science Foundation of China 82373699
6 · The paper itself

Abstract

High fluoride concentrations in groundwater represent a substantial global public health concern. In China, over 70 million individuals suffer from drinking water fluorosis. This study reports national surveillance data in 2014 and 2018, dividing affected areas into six regions. The compliance rate for safe fluoride concentrations in drinking water improved by 13.1%. The data revealed a statistically significant difference in fluoride concentration between areas that underwent improvements and those that did not (Z = - 10.583, P < 0.001). The potential health risks for minors were evaluated, with hazard index (HI) values for minors exceeding 1, indicating the possibility of non-carcinogenic health risks associated with fluoride exposure. Furthermore, in certain regions, the non-carcinogenic health risks related to the current Chinese national standard for fluoride in drinking water (1.0 mg/L) for infants have surpassed the acceptable threshold. The implementation of improvement initiatives led to a reduction in the non-carcinogenic risk of fluoride exposure for minors, with odds ratios (95% CI) for infants, children, and teens were 0.369 (0.268, 0.509), 0.556 (0.452, 0.683), and 0.823 (0.740, 0.914), respectively. These findings can assist governmental agencies in formulating more effective policies for the protection of minors, particularly infants, from fluoride exposure.

Indexed as

Drinking WaterFluoridesAdolescentChildChild, PreschoolChinaEnvironmental ExposureFemaleFluorosis, DentalGroundwaterHumansInfantMaleRisk AssessmentDrinking WaterFluoridesDrinking waterFluorideHealth riskMinors

Identifiers

PMID39738448
PMCPMC11685798

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.