Evidence map›Paper›PMID 39738384›Full record

ArticleScientific reports2024

An AMBRA1, ULK1 and PP2A regulatory network regulates cytotoxic T cell differentiation via TFEB activation.

Loredana Migliore, Valentina Cianfanelli, Fabrizia Zevolini, Monica Gesualdo, Leandro Marzuoli, Laura Patrussi, Cristina Ulivieri, Giuseppe Marotta, Francesco Cecconi, Francesca Finetti and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Loredana MiglioreDepartment of Life Sciences, University of Siena, Siena, Italy.
Valentina CianfanelliDepartment of Woman and Child Health and Public Health, Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Fabrizia ZevoliniDepartment of Life Sciences, University of Siena, Siena, Italy.
Monica GesualdoDepartment of Life Sciences, University of Siena, Siena, Italy.
Leandro MarzuoliDepartment of Life Sciences, University of Siena, Siena, Italy.
Laura PatrussiDepartment of Life Sciences, University of Siena, Siena, Italy.
Cristina UlivieriDepartment of Life Sciences, University of Siena, Siena, Italy.
Giuseppe MarottaSiena University Hospital, Siena, Italy.
Francesco CecconiUniversità Cattolica del Sacro Cuore and Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Francesca Finetti *Department of Life Sciences, University of Siena, Siena, Italy. finetti4@unisi.it.
Cosima T Baldari *Department of Life Sciences, University of Siena, Siena, Italy. cosima.baldari@unisi.it.

Funding

Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) IG 2017-20148Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) IG 2019-23543Dansk Kræftforskningsfond Fond (Danish Cancer Research Fund) R231-A14034EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC_2021_SyG 951329 - ATTACKMinistero della Salute (Ministry of Health, Italy) GR-2021-12372771Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PRIN 2022 Bando PNRR P2022TJZYZMinistero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PRIN bando 2017-2017FS5SHLNovo Nordisk Fonden (Novo Nordisk Foundation) 0070834
6 · The paper itself

Abstract

The scaffold protein AMBRA1, which participates in the autophagy pathway, also promotes CD4

Indexed as

Adaptor Proteins, Signal TransducingAutophagy-Related Protein-1 HomologBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCell DifferentiationProtein Phosphatase 2T-Lymphocytes, CytotoxicAnimalsAutophagyHumansIntracellular Signaling Peptides and ProteinsMiceAdaptor Proteins, Signal TransducingAMBRA1 protein, humanAutophagy-Related Protein-1 HomologBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsIntracellular Signaling Peptides and ProteinsProtein Phosphatase 2TFEB protein, humanULK1 protein, humanAMBRA1Cytotoxic T cellLytic granule /PP2A / ULK1

Identifiers

PMID39738384
PMCPMC11685475

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.