Evidence map›Paper›PMID 39738276›Full record

ArticleScientific reports2024

The dynamics of capillary flow in an open-channel system featuring trigger valves.

Jodie C Tokihiro, Ingrid H Robertson, Denise Gregucci, Albert Shin, Elisa Michelini, Tristan M Nicholson, Ayokunle O Olanrewaju, Ashleigh B Theberge, Jean Berthier, Erwin Berthier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Microfluidic valves for wearable sweat analysis: a review.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jodie C TokihiroDepartment of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA.
Ingrid H RobertsonDepartment of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA.
Denise GregucciDepartment of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA.
Albert ShinDepartment of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA.
Elisa MicheliniG. Ciamician Department of Chemistry, University of Bologna, Bologna, Italy.
Tristan M NicholsonDepartment of Urology, University of Washington, 1959 NE Pacific Street, Box 356510, Seattle, Washington, 98195, USA.
Ayokunle O OlanrewajuDepartment of Bioengineering, University of Washington, Box 355061, Seattle, Washington, 98195, USA.
Ashleigh B ThebergeDepartment of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA. abt1@uw.edu.
Jean BerthierDepartment of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA. berthj2@uw.edu.
Erwin BerthierDepartment of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA. erwin.berthier@gmail.com.

Funding

NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Theberge Admin Supp Undergraduate Summer Research ExperiencesR35GM128648 · NIGMS · UNIVERSITY OF WASHINGTON · PI Ashleigh Brooks Theberge · 2018 to 2026
$4.7M
University of Washington Pediatric and Reproductive Environmental Health Scholars (UW PREHS)K12ES033584 · NIEHS · UNIVERSITY OF WASHINGTON · PI CATHERINE J KARR, Sheela Sathyanarayana · 2022 to 2026
$2.4M
NCATS NIH HHS KL2 TR002317NCATS NIH HHS TL1 TR002318NIEHS NIH HHS K12 ES033584NIGMS NIH HHS R35 GM128648U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) KL2TR002317U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) TL1TR002318U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM128648
6 · The paper itself

Abstract

Trigger valves are fundamental features in capillary-driven microfluidic systems that stop fluid at an abrupt geometric expansion and release fluid when there is flow in an orthogonal channel connected to the valve. The concept was originally demonstrated in closed-channel capillary circuits. We show here that trigger valves can be successfully implemented in open channels. We also show that a series of open-channel trigger valves can be placed alongside or opposite a main channel resulting in a layered capillary flow. We developed a closed form model for the dynamics of the flow at trigger valves based on the concept of average friction length and successfully validated the model against experiments. For the main channel, we discuss layered flow behavior in the light of the Taylor-Aris dispersion theory and in the channel turns by considering Dean theory of mixing. This work has potential applications in autonomous microfluidics systems for biosensing, at-home or point-of-care sample preparation devices, hydrogel patterning for 3D cell culture and organ-on-a-chip models.

Indexed as

MicrofluidicsEquipment DesignLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesModels, TheoreticalCapillary microfluidicsFluid dynamicsFriction lengthOpen microfluidicsStop valvesTrigger valves

Identifiers

PMID39738276
PMCPMC11686082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.