Evidence map›Paper›PMID 39738230›Full record

ArticleScientific reports2024

Single unit-derived connectivity networks in tuberous sclerosis complex reveal propensity for network hypersynchrony driven by tuber-tuber interactions.

Aswin Chari, Amanda E Hernan, J Matthew Mahoney, Rachel Thornton, M Zubair Tahir, Martin M Tisdall, Rod C Scott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aswin ChariDevelopmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK.
Amanda E HernanDivision of Neuroscience, Nemours Children's Hospital, 1600 Rockland Road, Wilmington, Delaware, DE, 19803, USA.
J Matthew MahoneyThe Jackson Laboratory (Bar Harbor, Maine, USA.
Rachel ThorntonDepartment of Clinical Neurophysiology, Addenbrookes Hopsital, Cambridge, UK.
M Zubair TahirDepartment of Neurosurgery, Great Ormond Street Hospital, London, UK.
Martin M TisdallDevelopmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK.
Rod C ScottDevelopmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK. Rodney.scott@nemours.org.

Funding

Great Ormond Street Hospital Charity,United Kingdom VS0319
6 · The paper itself

Abstract

Network hypersynchrony is emerging as an important system-level mechanism underlying seizures, as well as cognitive and behavioural impairments, in children with structural brain abnormalities. We investigated patterns of single neuron action potential behaviour in 206 neurons recorded from tubers, transmantle tails of tubers and normal looking cortex in 3 children with tuberous sclerosis. The patterns of neuronal firing on a neuron-by-neuron (autocorrelation) basis did not reveal any differences as a function of anatomy. However, at the level of functional networks (cross-correlation), there is a much larger propensity towards hypersynchrony of tuber-tuber neurons than in neurons from any other anatomical site. This suggests that tubers are the primary drivers of adverse outcomes in children with tuberous sclerosis.

Indexed as

Nerve NetNeuronsTuberous SclerosisAction PotentialsAdolescentChildChild, PreschoolFemaleHumansMale

Identifiers

PMID39738230
PMCPMC11686100

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.