Differences between mates at the TLR1Lb locus are associated with lower reproductive success in a long-lived seabird.

Marianne Gousy-Leblanc, Thomas Merkling, Lila Colston-Nepali, Emma Lachance Linklater, Kyle H Elliott, Vicki L Friesen

Abstract read

In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Marianne Gousy-LeblancDepartment of Natural Resource Sciences, McGill University, Ste-Anne-de-Bellevue, QC, Canada. marianne.gousy-leblanc@mail.mcgill.ca.ORCID 0000-0001-7805-8120

Thomas MerklingDepartment of Natural Resource Sciences, McGill University, Ste-Anne-de-Bellevue, QC, Canada.ORCID 0000-0002-5878-0359

Lila Colston-NepaliDepartment of Biology, Queen's University, Kingston, ON, Canada.ORCID 0000-0003-2787-4210

Emma Lachance LinklaterDepartment of Biology, Queen's University, Kingston, ON, Canada.ORCID 0000-0001-9691-3979

Kyle H ElliottDepartment of Natural Resource Sciences, McGill University, Ste-Anne-de-Bellevue, QC, Canada.

Vicki L FriesenDepartment of Biology, Queen's University, Kingston, ON, Canada.ORCID 0000-0002-4921-1170

Funding

Canada Research Chairs Arctic EcologyFonds de recherche du Québec Merit scholarship for foreign student (PBEEE)Natural Sciences and Engineering Research Council of Canada Canada Graduate Scholarships-DoctoralNatural Sciences and Engineering Research Council of Canada Strategic Project

6 · The paper itself

Abstract

Genetic diversity can influence fitness components such as survival and reproductive success. Yet the association between genetic diversity and fitness based on neutral loci is sometime very weak and inconsistent, with relationships varying among taxa due to confounding effects of population demography and life history. Fitness-diversity relationships are likely to be stronger and more consistent for genes known to influence phenotypic traits, such as immunity-related genes, and may also depend on the genetic differences between breeding partners. We recorded breeding success of individuals and breeding pairs over 20 years to evaluate the relationships between reproductive success and both neutral genetic variation (using 7,830 single nucleotide polymorphisms) and functional variation (four toll-like receptor [TLRs] loci) with reproductive success in thick-billed murres (Uria lomvia). Individual genetic diversity (both neutral and functional) was unrelated to reproductive success, but surprisingly, successful multi-year reproductive success decreased with the genetic difference between breeding partners at TLR1Lb. This result may be due to an advantage of specific alleles at TLR1Lb. This study is one of few addressing both individual genetic variation and genetic similarity between mates at both neutral and functional variation in a long-lived bird.

Indexed as

CharadriiformesPolymorphism, Single NucleotideReproductionAllelesAnimalsFemaleGenetic VariationLongevityMaleBrünnich’s guillemotImmunitySingle-nucleotide polymorphismThick-billed murreToll-like receptors

Identifiers

PMID39738121

DOI10.1038/s41598-024-77750-7

PMCPMC11686313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.