ArticleNature communications2024
Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
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Who cites it
15 citing papers in PubMed.
- Review
- Clonal Metamorphosis: Deconstructing MPN Evolution with Single-Cell and Spatial Multi-Omics.Clinical and experimental medicine · 2026Review
- Mitochondrial integrated stress response activation creates a therapeutic vulnerability to MCL-1 inhibition in acute myeloid leukemia.Cell death & disease · 2026Article
- Article
- Multi-parametric profiling of plasma-derived extracellular vesicles reveals a disease-associated molecular signature supporting a liquid biopsy approach in myelofibrosis.Molecular medicine (Cambridge, Mass.) · 2026Article
- Novel insights into extracellular vesicles: An update on biomolecules, immunomodulation and clinical strategies in skin melanoma.Clinical and translational medicine · 2026Review
- Review
- The distinct roles of ROS in tumor immunity: from mechanisms to immunotherapeutic applications.Journal of hematology & oncology · 2026Review
- Hijacking the helpers: platelet and neutrophil trafficking in AML and therapeutic exploitation.Experimental hematology & oncology · 2026Review
- Understanding hairy cell leukemia in the context of mature B-cell neoplasms: tumor microenvironment and extracellular vesicle contribution to disease pathogenesis.Frontiers in immunology · 2026Review
- Regulating Ferroptosis in Leukemic Stem Cells: From Stemness Preservation to Targeted Differentiation Strategies.Stem cell reviews and reports · 2026Review
- A multidimensional landscape of extracellular vesicle-mediated tumor drug resistance: mechanisms, biomarkers, engineered drug delivery, and clinical translation.Extracellular vesicles and circulating nucleic acids · 2026Review
- Metabolism in hematology: Technological advances open new perspectives on disease biology and treatment.HemaSphere · 2025Review
- Precision cardiovascular medicine: shifting the innovation paradigm.Frontiers in science · 2025Article
- Decoding cardiac metabolic reprogramming through single-cell multi-omics: from mechanisms to therapeutic applications.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
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Authors and funding
26 authors.
Dorian ForteDepartment of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.ORCID 0000-0002-8443-605X
Roberto Maria PellegrinoDepartment of Chemistry, Biology and Biotechnology, Biochemical and Biotechnological Sciences Section, University of Perugia, Perugia, Italy.ORCID 0000-0001-5594-383X
Paolo FalvoLaboratory of Hematology-Oncology, European Institute of Oncology IRCCS, Milan, Italy.ORCID 0000-0001-5743-5046
Paulina Garcia-GonzalezAix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Husam B R AlabedDepartment of Chemistry, Biology and Biotechnology, Biochemical and Biotechnological Sciences Section, University of Perugia, Perugia, Italy.
Filippo MaltoniDepartment of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.
Davide LombardiLaboratory of Hematology-Oncology, European Institute of Oncology IRCCS, Milan, Italy.
Samantha BrunoDepartment of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.ORCID 0000-0001-6375-0595
Martina BaroneIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.ORCID 0000-0003-3356-9861
Federico PasiniDepartment of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.ORCID 0009-0000-1719-1585
Francesco FabbriBiosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Ivan VanniniBiosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Benedetta DonatiLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Gianluca CristianoDepartment of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.
Chiara SartorDepartment of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.
Simona RonzoniDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milano, Italy.
Alessia CiarrocchiLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.ORCID 0000-0002-5541-2075
Sandra BurattaDepartment of Chemistry, Biology and Biotechnology, Biochemical and Biotechnological Sciences Section, University of Perugia, Perugia, Italy.
Lorena UrbanelliDepartment of Chemistry, Biology and Biotechnology, Biochemical and Biotechnological Sciences Section, University of Perugia, Perugia, Italy.ORCID 0000-0003-0621-8476
Carla EmilianiDepartment of Chemistry, Biology and Biotechnology, Biochemical and Biotechnological Sciences Section, University of Perugia, Perugia, Italy.
Simona SoveriniDepartment of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.
Lucia CataniDepartment of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.
Francesco BertoliniLaboratory of Hematology-Oncology, European Institute of Oncology IRCCS, Milan, Italy.ORCID 0000-0001-5660-3255
Rafael José ArgüelloAix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0000-0001-9785-3883
Michele CavoDepartment of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.
Antonio CurtiIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy. antonio.curti2@unibo.it.ORCID 0000-0002-7752-6049
Funding
Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) 20654Ministry of Health, Italy | Agenzia Italiana del Farmaco, Ministero della Salute (Italian Medicines Agency) RC-2023-2778890
Abstract
Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34
Indexed as
Extracellular VesiclesLeukemia, Myeloid, AcuteMitochondriaSingle-Cell AnalysisAdultAgedAnimalsAntigens, CD34Cell Line, TumorFemaleGlutathioneGlutathione PeroxidaseGlycolysisHumansMaleMetabolomeAntigens, CD34GlutathioneGlutathione PeroxidaseGPX3 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.