ArticleNature communications2024
Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Transcranial pulse stimulation modulates spectral signatures of Alzheimer's disease in the 3×Tg-AD mouse model.Alzheimer's research & therapy · 2026Article
- All-fiber photoacoustic endomicroscopy reveals layer-specific angiogenesis-oxygenation uncoupling in experimental colitis.Science advances · 2026Article
- Hypercapnia dissociates neuronal and hemodynamic responses impairing neurovascular coupling and functional brain connectivity.Nature communications · 2026Article
- Pancreatic amylin dynamically reconfigures distributed brain networks governing appetite regulation in mice.Molecular metabolism · 2026Article
- Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging.Science advances · 2025Article
- Multiview linear-array photoacoustic computed tomography with improved elevational resolution in 3D.Biomedical optics express · 2025Article
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Non-invasive large-scale imaging of concurrent neuronal, astrocytic, and hemodynamic activity with hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI).Light, science & applications · 2025Article
- Transcranial pulse stimulation modulates neuronal activity and functional network dynamics.Brain stimulationArticle
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Authors and funding
6 authors.
Funding
Abstract
Resting-state functional connectivity (rsFC) has been essential to elucidate the intricacy of brain organization, further revealing clinical biomarkers of neurological disorders. Although functional magnetic resonance imaging (fMRI) remains a cornerstone in the field of rsFC recordings, its interpretation is often hindered by the convoluted physiological origin of the blood-oxygen-level-dependent (BOLD) contrast affected by multiple factors. Here, we capitalize on the unique concurrent multiparametric hemodynamic recordings of a hybrid magnetic resonance optoacoustic tomography platform to comprehensively characterize rsFC in female mice. The unique blood oxygenation readings and high spatio-temporal resolution at depths provided by functional optoacoustic (fOA) imaging offer an effective means for elucidating the connection between BOLD and hemoglobin responses. Seed-based and independent component analyses reveal spatially overlapping bilateral correlations between the fMRI-BOLD readings and the multiple hemodynamic components measured with fOA but also subtle discrepancies, particularly in anti-correlations. Notably, total hemoglobin and oxygenated hemoglobin components are found to exhibit stronger correlation with BOLD than deoxygenated hemoglobin, challenging conventional assumptions on the BOLD signal origin.
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