Evidence map›Paper›PMID 39737854›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Hspa13 Deficiency Impaired Marginal Zone B Cells Regulatory Function and Contributed to Lupus Pathogenesis.

Chen Xing, Haoran Cui, Ge Li, Xiaoling Liu, Kun Liu, Qing Wen, Xin Huang, Renxi Wang, Lun Song

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen XingBeijing Institute of Basic Medical Sciences, Beijing, 100850, China.ORCID https://orcid.org/0000-0003-2784-840X
Haoran CuiBeijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Ge LiBeijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Xiaoling LiuDepartment of Dermatology, First Medical Centre of Chinese, PLA General Hospital, Beijing, 100853, China.
Kun LiuBeijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Qing WenBeijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Xin HuangBeijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Renxi WangBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China.
Lun SongBeijing Institute of Basic Medical Sciences, Beijing, 100850, China.

Funding

Beijing Natural Science Foundation 7222121
6 · The paper itself

Abstract

Dysregulated IL-10 producing regulatory B cells (Bregs) are associated with the progression of systemic lupus erythematosus. An immunomodulatory role of heat shock proteins (HSPs) is implicated in autoimmune diseases. However, the molecular basis underlying the role of Hspa13 in regulating Bregs function and lupus pathogenesis remains unclear. In this study, Bregs display higher Hspa13 expression than IL-10

Indexed as

B-Lymphocytes, RegulatoryHSP70 Heat-Shock ProteinsLupus Erythematosus, SystemicAnimalsDisease Models, AnimalFemaleInterleukin-10MiceMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutT-Lymphocytes, RegulatoryHSP70 Heat-Shock ProteinsInterleukin-10Hspa13IL‐10MZ B cellsregulatory B cellsregulatory T cellsSLE

Identifiers

PMID39737854
PMCPMC11848637

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.