Evidence map›Paper›PMID 39737831›Full record

ArticleOral diseases2025

Changes in Disc Status and Condylar Regeneration After Intracapsular Condylar Fractures in Rabbits.

Siwei Xu, Kaixin Yan, Linli Jiang, Xinnan Chang, Hui Li, Lei Liu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Oral diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Siwei XuState Key Laboratory of Oral Disease & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0001-9775-7901
Kaixin YanState Key Laboratory of Oral Disease & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Linli JiangState Key Laboratory of Oral Disease & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Xinnan ChangDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Hui LiState Key Laboratory of Oral Disease & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-6841-2229
Lei LiuDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-5309-1979

Funding

National Natural Science Foundation of ChinaSichuan Provincial Science and Technology Support Program
6 · The paper itself

Abstract

backgroundThe treatment procedure for intracapsular condylar fractures (ICF) is still being debated. The temporomandibular joint (TMJ) disc is a key factor for treating ICF. The study aims to investigate the changes in TMJ disc status and condylar cartilage regeneration following ICF in a rabbit model, to assist in planning treatment.

methodsAdolescent and adult rabbits received surgery on the left TMJs: (1) ICF with anterior disc displacement, (2) ICF with the removal of the ICF segment and disc. The animals were euthanized immediately, and at 4, 8, and 12 weeks after surgery. Their left TMJs were collected for histological, SOX 9 immunohistochemical, and micro-CT analyses.

resultsAll 36 TMJs (100%) showed anterior disc displacement at 4, 8, and 12 weeks after surgery. Also, condylar cartilage regeneration was observed in all 36 joints. Notably, partial regeneration of condylar cartilage was noted at 4 weeks after removal of the disc and ICF fractured segment in both adolescent and adult groups.

conclusionAnterior displaced disc after ICF in adolescent and adult rabbits exhibited sustained disc displacement without therapeutic intervention. TMJ disc and associated attachment are crucial in the condylar cartilage regeneration after ICF.

Indexed as

Mandibular CondyleMandibular FracturesRegenerationTemporomandibular Joint DiscAnimalsCartilage, ArticularDisease Models, AnimalMaleRabbitsSOX9 Transcription FactorX-Ray MicrotomographySOX9 Transcription Factoranterior disc displacementcartilageintracapsular condylar fracturerabbittemporomandibular joint

Identifiers

PMID39737831
PMCPMC12291424

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.