Evidence map›Paper›PMID 39737774›Full record

ArticleOral diseases2025

Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours.

Pepijn J P van der Aa, Max J H Witjes, Bert van der Vegt, Ed Schuuring, Koos Boeve, Grigory Sidorenkov, Geertruida H de Bock, Sebastiaan A H J de Visscher

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In one paragraph

Article in Oral diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pepijn J P van der AaDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-1790-0032
Max J H WitjesDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bert van der VegtDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ed SchuuringDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Koos BoeveDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Grigory SidorenkovDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Geertruida H de BockDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Sebastiaan A H J de VisscherDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD). MATERIALS AND

methodsNewly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).

results185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).

conclusionNSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.

Indexed as

Alcohol DrinkingCarcinoma, Squamous CellMouth NeoplasmsNeoplasms, Second PrimaryNon-SmokersSmokingAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalProportional Hazards ModelsProspective Studiesalcoholclinicopathological featuresoral cancerrecurrencesecond primary tumoursmoking

Identifiers

PMID39737774
PMCPMC12319359

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.