Evidence map›Paper›PMID 39737693›Full record

ArticleMagnetic resonance in medicine2025

Detection of elevated succinate in brain during circulatory arrest in a piglet model: A 3T

Ralph E Hurd, Meng Gu, Kenichi Okamura, Masafumi Shibata, Yoshikazu Ono, Moussa Haidar, R Kirk Riemer, Frank L Hanley, Daniel M Spielman

Abstract read
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In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. PreclinicalMagnetic resonance in medicine · 2026
    Article
  2. Article
  3. Article
  4. Rescuing Ischemic Brain Injury by Rewiring Mitochondrial Electron Flow.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ralph E HurdDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0009-0000-7523-685X
Meng GuDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.
Kenichi OkamuraDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.
Masafumi ShibataDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.
Yoshikazu OnoDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.
Moussa HaidarDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.
R Kirk RiemerDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-3054-9809
Frank L HanleyDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.
Daniel M SpielmanDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-0838-6967

Funding

Neurometabolic Outcomes of Different Cardiopulmonary Bypass StrategiesR01HL152757 · NHLBI · STANFORD UNIVERSITY · PI HANLEY, FRANK, SPIELMAN, DANIEL M · 2021 to 2024
$2.9M
NHLBI NIH HHS R01 HL152757NIH HHS R01 HL152757
6 · The paper itself

Abstract

purposeTo measure and validate elevated succinate in brain during circulatory arrest in a piglet model of cardiopulmonary bypass.

methodsUsing data from an archive of 3T

resultsElevation of succinate during circulatory arrest was observed and validated. Fitting bias was evaluated as a function of the line-widths and signal-to-noise ratios of the archived data. Succinate increases were independent of bypass temperature. Succinate elevation was also not observed with antegrade cerebral perfusion.

conclusionAlthough spectrally overlapped and at sub-millimolar levels, elevated brain succinate can be reliably measured by dynamic MR spectroscopy at 3T. Noise dependent bias of the stronger overlapping signals did not impact the succinate measurement. Elevated succinate during circulatory arrest and its recovery after reperfusion was observed. This finding is consistent with earlier reports that correlate elevated succinate with ischemic-reperfusion injury.

Indexed as

BrainProton Magnetic Resonance SpectroscopySuccinic AcidAnimalsCardiopulmonary BypassDisease Models, AnimalMagnetic Resonance SpectroscopyReproducibility of ResultsSwineSuccinic Acidcirculatory arrestischemic recovery injuryMR spectroscopysuccinatesynthetic MRS

Identifiers

PMID39737693
PMCPMC13277797

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.