Evidence map›Paper›PMID 39737621›Full record

ArticleClinical transplantation2025

Do Factors Influencing Acceptance of Kidney Stone Formers as Donors Predict Subsequent Stone Events?

Mira T Keddis, Matthew R Howard, Nan Zhang, Jaxon K Quillen, Matthew R D'Costa, Hasan A Khamash, Carrie C Jadlowiec, Hani M Wadei, Ivan E Porter, Karen L Stern and 1 more

Abstract read
In one paragraph

Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mira T KeddisDivision of Nephrology and Hypertension, Mayo Clinic, Scottsdale, Arizona, USA.ORCID https://orcid.org/0000-0001-8249-0848
Matthew R HowardMayo Clinic Alix School of Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
Nan ZhangDepartment of Quantitative Health Sciences, Mayo Clinic, Scottsdale, Arizona, USA.
Jaxon K QuillenDepartment of Quantitative Health Sciences, Mayo Clinic, Scottsdale, Arizona, USA.
Matthew R D'CostaDivision of Nephrology and Hypertension, National University Hospital,  , Singapore.
Hasan A KhamashDivision of Nephrology and Hypertension, Mayo Clinic, Scottsdale, Arizona, USA.
Carrie C JadlowiecDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, USA.ORCID https://orcid.org/0000-0001-7860-9519
Hani M WadeiDivision of Nephrology, Mayo Clinic, Jacksonville, Florida, USA.ORCID https://orcid.org/0000-0003-4886-0897
Ivan E PorterDivision of Nephrology, Mayo Clinic, Jacksonville, Florida, USA.ORCID https://orcid.org/0000-0002-6366-8548
Karen L SternDepartment of Urology, Mayo Clinic, Phoenix, Arizona, USA.
Andrew D RuleDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to assess whether kidney stone burden and risk factors at the time of kidney donor evaluation were associated with a symptomatic stone event post-donor evaluation.

methodsWe identified adults evaluated at Mayo Clinic (two sites) (2000-2011) for living kidney donation and had either a personal history or radiological evidence of kidney stone disease. We analyzed demographics, stone risk factors, stone number/size, and the committee's donation decision and reasons. A follow-up survey (2022-2023) assessed post-evaluation symptomatic kidney stones and related morbidity.

resultsAmong 412 potential donors with kidney stone disease, 258 donated, 75 did not donate due to kidney stones, and 79 did not donate for other reasons. Multivariable analysis showed that candidates not donating due to stones had higher body mass index (BMI), prior symptomatic kidney stones, multiple stones on imaging, bilateral kidney stones, and diameter of largest stone ≥3 mm. Of 147 who completed the survey, 26 (18%) had a symptomatic kidney stone post-donor evaluation. Younger age (p = 0.031) and multiple stones on imaging (p = 0.02) were significant predictors of post-evaluation symptomatic stones regardless of donation status (p = 0.41).

conclusionsStone burden on imaging and prior symptomatic stone events were associated with not donating. Younger age and stone burden on imaging were the primary risk factors for a symptomatic kidney stone event after donor evaluation.

Indexed as

Kidney CalculiKidney TransplantationLiving DonorsAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedNephrectomyPrognosisRetrospective StudiesRisk Factorskidney donationkidney donorskidney stonesstone formers

Identifiers

PMID39737621
PMCPMC11687201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.