Evidence map›Paper›PMID 39737471›Full record

ArticleAllergy2025

BLOC1S1 Control of Vacuolar Organelle Fidelity Modulates Murine T

Rahul Sharma, Kaiyuan Wu, Kim Han, Anna Chiara Russo, Pradeep K Dagur, Christian A Combs, Xianglan Yao, Stewart J Levine, Michael N Sack

Abstract read
In one paragraph

Article in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. BLOC1S1 regulates autolysosomal and exosomal dynamics during CD4bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. TAT-PBX1 fusion protein alleviates LPS-induced acute lung injury via AMPK-TFAM signaling activation.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rahul SharmaLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, Maryland, USA.
Kaiyuan WuCardiovascular Branch, NHLBI, NIH, Bethesda, Maryland, USA.
Kim HanLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, Maryland, USA.
Anna Chiara RussoLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, Maryland, USA.
Pradeep K DagurFlow Cytometry Core, NHLBI, NIH, Bethesda, Maryland, USA.
Christian A CombsLight Microscopy Core, NHLBI, NIH, Bethesda, Maryland, USA.
Xianglan YaoCritical Care Medicine and Pulmonary Branch, Bethesda, Maryland, USA.
Stewart J LevineCritical Care Medicine and Pulmonary Branch, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-9313-9746
Michael N SackLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-3411-0000

Funding

Mitochondrial Biology in DiseaseZIAHL005102 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2009 to 2025
$22.7M
Mitochondrial biology in diabetesZ01HL005199 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2007 to 2008
$3.5M
Intramural NIH HHS Z01 HL005199Intramural NIH HHS ZIA HL005102NHLBI Division of Intramural Research
6 · The paper itself

Abstract

backgroundThe levels of biogenesis of lysosome organelles complex 1 subunit 1 (BLOC1S1) control mitochondrial and endolysosome organelle homeostasis and function. Reduced fidelity of these vacuolar organelles is increasingly being recognized as important in instigating cell-autonomous immune cell activation. We reasoned that exploring the role of BLOC1S1 in CD4

methodsCD4

resultsT

conclusionsBLOC1S1 depletion in mouse CD4

Indexed as

HypersensitivityTh2 CellsVacuolesAnimalsCytokinesDisease Models, AnimalDisease SusceptibilityMiceMice, KnockoutNF-kappa BSignal TransductionCytokinesNF-kappa Banimal modelssignal transductionT cells

Identifiers

PMID39737471
PMCPMC12206928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.