Evidence map›Paper›PMID 39737432›Full record

ArticleJournal of experimental orthopaedics2025

Medial patellofemoral ligament reconstruction normalizes patellar kinematics but fails to predict cartilage contact area: A prospective 3D MRI study.

Markus Siegel, Philipp Maier, Elham Taghizadeh, Hans Meine, Thomas Lange, Andreas Fuchs, Tayfun Yilmaz, Hagen Schmal, Kaywan Izadpanah

Abstract read
In one paragraph

Article in Journal of experimental orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Markus SiegelDepartment of Orthopedic Surgery and Traumatology, Freiburg University Hospital Albert Ludwigs University Freiburg Freiburg Germany.ORCID 0000-0002-9466-2157
Philipp MaierDepartment of Orthopedic Surgery and Traumatology, Freiburg University Hospital Albert Ludwigs University Freiburg Freiburg Germany.
Elham TaghizadehFraunhofer Institute for Digital Medicine MEVIS Bremen Germany.
Hans MeineFraunhofer Institute for Digital Medicine MEVIS Bremen Germany.
Thomas LangeDivision of Medical Physics, Department of Diagnostic and Interventional Radiology Medical Center, Faculty of Medicine University of Freiburg Freiburg Germany.
Andreas FuchsDepartment of Orthopedic Surgery and Traumatology, Freiburg University Hospital Albert Ludwigs University Freiburg Freiburg Germany.
Tayfun YilmazDepartment of Orthopedic Surgery and Traumatology, Freiburg University Hospital Albert Ludwigs University Freiburg Freiburg Germany.
Hagen SchmalDepartment of Orthopedic Surgery and Traumatology, Freiburg University Hospital Albert Ludwigs University Freiburg Freiburg Germany.
Kaywan IzadpanahDepartment of Orthopedic Surgery and Traumatology, Freiburg University Hospital Albert Ludwigs University Freiburg Freiburg Germany.

Funding

RGR-based motion tracking for real-time adaptive MR imaging and spectroscopyR01DA021146 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, THOMAS M · 2007 to 2018
$8.6M
NIDA NIH HHS R01 DA021146
6 · The paper itself

Abstract

Introduction: The medial patellofemoral ligament (MPFL) is the main patellar stabilizer in low knee flexion degrees (0-30°). Isolated MPFL reconstruction (MPFLr) is therefore considered the gold standard of surgical procedures for low flexion patellofemoral instabilities (PFIs). Despite excellent clinical results, little is known about the effect of MPFLr on kinematic parameters (KPs) of the patellofemoral joint in vivo. This study investigates the effect of MPFLr on KP of patellofemoral articulation, using a three-dimensional (3D) in vivo magnetic resonance imaging (MRI) analysis at different flexion and loading positions, and analyzes the correlation of these parameters with the patellofemoral cartilage contact area (CCA). Methods: In this prospective, matched-pair cohort study of 30 individuals, 15 patients with low flexion PFI and 15 knee-healthy individuals were included. Patients were analyzed pre and post-operatively after MPFLr. MRI images were obtained at 0°, 15° and 30° with and without muscle activation, using a custom-designed pneumatic loading device. Patellar shift, tilt and rotation were determined in 3D bone and cartilage models of each individual, guaranteeing the highest reliability. Subsequently, the KPs were correlated with patellofemoral CCA. Results: Patients with low flexion PFI had a leg geometry of 0.5 ± 2.6° valgus and a TTTG of 11.4 ± 4.4 mm. Eleven patients had moderate (Type A/B) and 2 had severe (Type C/D) trochlear dysplasia. Without muscle activation, patients showed significantly increased patellar shift (0-30°; Conclusion: Isolated MPFLr can normalize patellar shift and tilt in patients with low flexion instability. Considering the influence of muscle activation, passive stabilization through MPFLr seems to be the basic precondition for physiologically active patella stabilization. The investigated KPs as easy-to-measure parameters in clinical practice cannot be used to assume normalized CCA for low flexion degrees. Therefore, methodologically demanding methods are still required to calculate the patellofemoral CCA. Level of Evidence: Level II.

Indexed as

dynamickneeMPFLMRIpatellofemoral

Identifiers

PMID39737432
PMCPMC11683773

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.