Evidence map›Paper›PMID 39737396›Full record

ArticleFrontiers in oncology2024

A phase I study using bortezomib (Velcade), cladribine, and rituximab in treating patients over 50 years old with mantle cell lymphoma.

Jeffrey J Pu, Kristin N Berger, Chunlei Zheng, Nhan Do, David F Claxton, W Christopher Ehmann, Joseph J Drabick, Haiquan Li, Thomas P Loughran, Elliot M Epner

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01439750 (Bortezomib), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01439750 phase1unknown statusnot on this map

Bortezomib (VELCADE), Cladribine and Rituximab (VCR) in Mantle Cell Lymphoma: A Phase I/II Study (PSHCI 10-011)

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2012 to 2020Enrolled13ConditionsMantle Cell LymphomaArmsRituximab, bortezomib, Cladribine
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jeffrey J PuDivision of Medicine, VA Boston Healthcare System, Boston, MA, United States.
Kristin N BergerNew York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, United States.
Chunlei ZhengDivision of Medicine, VA Boston Healthcare System, Boston, MA, United States.
Nhan DoDivision of Medicine, VA Boston Healthcare System, Boston, MA, United States.
David F ClaxtonPenn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, United States.
W Christopher EhmannPenn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, United States.
Joseph J DrabickPenn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, United States.
Haiquan LiDepartment of Biosystems Engineering, University of Arizona, Tucson, AZ, United States.
Thomas P LoughranDepartment of Medicine, University of Virginia National Cancer Institute (NCI) Designated Comprehensive Cancer Center, Charlottesville, VA, United States.
Elliot M EpnerPenn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cladribine indirectly downregulates methylation of DNA, RNA, and histones by blocking the transfer of methyl groups from Clinical Trial Registration: ClinicalTrials.gov, identifier NCT01439750.

Indexed as

cladribinecombination (combined) therapyepigeneticmantle cell lymphoma (MCL)phase I trial

Identifiers

PMID39737396
PMCPMC11683081

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.