Article3 Biotech2025
Comparing the effectiveness of curcumin and papain in wound dresses based on chitosan nanoparticle.
Article in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Chitosan/reduced graphene oxide/papain nanocomposite: a bioactive platform for skincare and biomedical applications.Scientific reports · 2026Article
- Chitosan-Nanoencapsulated Curcumin for the Treatment of Diabetic Foot Ulcers: A Review.Polymers · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, chitosan/curcumin (CS/Cur) and chitosan/papain (CS/Pa) nanoparticles were prepared and then characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), and differential light scattering (DLS). Subsequently, release rate, porosity, swelling, degradability, anti-inflammatory, antioxidant, antibacterial, and cell viability tests were conducted to investigate and compare the healing potential of the nanoparticles for various types of wounds. The results of FTIR, XRD, and DLS indicated that the nanoparticles were manufactured correctly with a hydrodynamic diameter of 429 nm (CS/Cur) and 460 nm (CS/Pa), and zeta potential of 4.32 mV (CS/Cur) and 7.57 mV (CS/Pa). The release rate results indicated a higher release rate in a basic environment (pH 8.4) for curcumin, a higher release rate for papain in an acidic environment (pH 6.4), and the Korsmeyer-Peppas model for the release of curcumin and papain. The results indicated that CS/Cur with 41.6% antioxidant activity, high antibacterial effect, and cell growth up to 616% during 7 days, was more effective than CS/Pa. In comparison, CS/Pa (with a porosity of 70.5% and a swelling rate of 1392%) was more advantageous than CS/Cur in terms of porosity and swelling. In addition, CS/Cur was as effective as CS/Pa in terms of degradation and anti-inflammatory properties. In conclusion, the outcomes represented that the CS/Cur and CS/Pa nanoparticles improved wound healing, and each was suitable for specific wounds and wound healing stages.
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Registered trials
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