ArticleCureus2024
High Silent Prevalence of Zinc Deficiency and Impaired Immunity in Children Under Five Years of Age Admitted to a Regional Referral Hospital in Uganda.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Introduction Zinc deficiency (ZnD) impairs the development of acquired immunity and contributes to growth failure in children under five years of age. However, the prevalence of ZnD and its association with immunity in this age group in Uganda have not been well explored. This study aimed to determine the prevalence of ZnD and explore the associations between low serum zinc levels and total white blood cell count, differential cell counts, and levels of IL-1 and IL-2 in children aged 12 to 59 months. Methods In this cross-sectional study, we enrolled children aged 12 to 59 months upon admission to the pediatrics ward of Masaka Regional Referral Hospital (MRRH), located in Masaka City, Southern Uganda. Anthropometric measurements were taken and interpreted using the WHO growth standards charts for age and sex. Whole blood cell counts, serum zinc levels, CRP, and IL-2 and IL-4 were measured. Student's t-test, Mann-Whitney test, and correlation coefficients were used to assess relationships between variables. Results A total of 40 children (mean age 27.8 (SD 10.6) months; 50% boys) were enrolled. Nearly a third (13/40) of the children were malnourished (22.5% stunted and 12.5% wasted), and 82.5% had anemia (Hb <11.0 g/dL). The prevalence of ZnD was 40.6%. Serum zinc levels showed a positive correlation with total white blood cell count (r
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