ArticleCureus2024
Diagnostic Accuracy of High-Resolution Computed Tomography (HRCT) in Detecting Pneumocystis carinii in Renal Transplant Patients With Pulmonary Infection: A Study Using Bronchoalveolar Lavage As the Gold Standard.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Dual drug co-encapsulation into liposomes and liposome-derived nanosystems for improved synergistic treatment of skin diseases.Drug delivery and translational research · 2026Review
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionPatients receiving renal transplants have weakened immune systems and are more vulnerable to lung infections.
objectivesTo determine the diagnostic accuracy of high-resolution computed tomography (HRCT) in detecting pneumocystis carinii in renal transplant patients presenting with pulmonary infection in a tertiary care transplant center, keeping bronchoalveolar lavage (BAL) as the gold standard.
methodsThis cross-sectional study was conducted at the Department of Radiology, Sindh Institute of Urology and Transplant, Karachi, from February 14, 2023, to August 13, 2023. Using a non-probability consecutive sampling technique, we enrolled 81 post-renal transplant patients, aged 20 to 60 years, of both genders, who were receiving immunosuppressive therapy and referred to the Radiology Department for HRCT as part of a workup for pulmonary infection. Patients presented with pulmonary infection underwent HRCT and BAL. Diagnostic accuracy was determined and data was analyzed.
resultsIn this study, 81 patients were enrolled with a mean age of 35.4±11.3 years. There were 56 (69.1%) male and 25 (30.9%) female patients. The mean duration of renal transplant was 18.09±12.8 months. The mean duration of symptoms was 5.32±2 days. Diabetes was present in 43 (53.1%) patients. The sensitivity of HRCT in diagnosing pneumocystis carinii was 93%, specificity was 91.7%, positive predictive value was 96.4%, negative predictive value was 84.6%, and diagnostic accuracy was 92.5%, taking BAL as the gold standard.
conclusionHRCT is a good imaging modality to diagnose pneumocystis carinii in renal transplant patients.
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