Evidence map›Paper›PMID 39737196›Full record

ArticleFrontiers in immunology2024

TREM-1 and TREM-2 as therapeutic targets: clinical challenges and perspectives.

Alexander B Sigalov

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Alexander B SigalovSignaBlok, Inc., Shrewsbury, MA, United States.

Funding

First-in-class TREM-1 inhibitors in combination therapy for pancreatic cancerR44CA217400 · NCI · SIGNABLOK, INC. · PI SIGALOV, ALEXANDER B · 2019 to 2020
$2.0M
First-in-class TREM-1 inhibitors for neovascular retinal diseasesR44EY034015 · NEI · SIGNABLOK, INC. · PI Alexander B Sigalov · 2023 to 2026
$1.9M
New mechanism-based TREM-1 therapy for acute respiratory distress syndromeR43HL165734 · NHLBI · SIGNABLOK, INC. · PI SIGALOV, ALEXANDER B · 2023 to 2023
$273k
Novel TREM-1 targeting therapies for sepsisR43GM128369 · NIGMS · SIGNABLOK, INC. · PI SIGALOV, ALEXANDER B · 2018 to 2018
$225k
NCI NIH HHS R44 CA217400NEI NIH HHS R44 EY034015NHLBI NIH HHS R43 HL165734NIGMS NIH HHS R43 GM128369
6 · The paper itself

Abstract

TREM-1 and TREM-2 as Therapeutic Targets: Clinical Challenges and Perspectives.

Indexed as

Membrane GlycoproteinsReceptors, ImmunologicTriggering Receptor Expressed on Myeloid Cells-1AnimalsHumansMolecular Targeted TherapyMembrane GlycoproteinsReceptors, ImmunologicTREM1 protein, humanTREM2 protein, humanTriggering Receptor Expressed on Myeloid Cells-1antagonists & inhibitorsclinical trial failuredrug discovery & developmentinflammationligand-independent inhibitionmultiligand receptorsTREM-1TREM-2

Identifiers

PMID39737196
PMCPMC11682994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.