Evidence map›Paper›PMID 39737133›Full record

ArticleCytoJournal2024

Adenosine deaminase acting on RNA 2 provides neuroprotection by activating Kv1.1 channels in a rat epilepsy model.

Pingping Zhu, Wei Yuan, Wenquan Liu, Jian Wu, Pengzhen Wang, Bo Ning

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CytoJournal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pingping Zhu *Department of Neurology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.
Wei Yuan *Department of General Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.
Wenquan LiuDepartment of Rehabilitation Medicine, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.
Jian WuDepartment of General Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.
Pengzhen WangDepartment of Traumatic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.
Bo NingDepartment of Neurosurgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Potassium voltage-gated channel sub-family A member 1 (Kv1.1), as a shaker homolog potassium channel, displays a special mechanism for posttranscriptional regulation called RNA editing. Adenosine deaminase acting on RNA 2 (ADAR2) can cause abnormal editing or loss of normal editing, which results in cell damage and related diseases. The relationship between Kv1.1 and editing enzyme ADAR2 in epileptic rats remains incompletely understood. We aimed to investigate the neuroprotective role of ADAR2 and its relationship with Kv1.1 in epileptic rats and the SH-SY5Y neuroblastoma cell line. Material and Methods: A rat epilepsy model was induced Results: The overexpression of ADAR2 in epileptic rats led to the increased mRNA and protein expression of Kv1.1 ( Conclusion: Our findings confirm that the upregulation of ADAR2 promotes Kv1.1 protein expression, which ultimately reduces neuronal damage in the hippocampus of animals with epilepsy.

Indexed as

Adenosine deaminase acting on RNA 2EpilepticHippocampusNeuronPotassium voltage-gated channel subfamily A member 1

Identifiers

PMID39737133
PMCPMC11683407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.