ArticleOpen veterinary journal2024
Possible relationship between pre-pregnancy maternal body mass index and offspring hippocampus: An experimental study in albino Wistar rat.
Article in Open veterinary journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Cognitive impairment and attention deficit disorder have been on the rise among generations in recent times. A significant portion of the brain involved in learning and cognition is the hippocampus. Its development begins in utero till weaning. The mother's body mass index (BMI) before pregnancy indicates her health; however, little data links maternal BMI before pregnancy to fetal hippocampal health outcomes. Aim: The study aimed to estimate the extent to which pre-pregnancy maternal BMI relates to their offspring brain status, and thus to what extent to this stage of life may be an opportunity for mental and cognitive development. Methods: Thirty-six naive female albino rats ( Results: The present findings manifested elevation in the inflammatory and apoptotic markers in the hippocampus of underweight mothers-offspring yielding a lower cognitive ability than overweight mothers-offspring compared to those whose mothers with normal weight before conception. The male offspring were more affected than female offspring especially those born to pre-pregnancy underweight mothers. Conclusion: The study concluded that there may be a connection between a mother's pre-pregnancy BMI and her offspring's cognitive capacities, which calls for more study to gain a deeper knowledge and to create interventions that target the physical health of the mother prior to pregnancy in order to enhance their offspring's health and cognitive outcomes.
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