Evidence map›Paper›PMID 39737041›Full record

ArticleOpen veterinary journal2024

Histological evaluation of the regenerative potential of injectable hyaluronic acid hydrogel or collagen with blood clot as scaffolds during revascularization of immature necrotic dog's teeth.

Mohamed S Abdelsalam, Abeer A Elgendy, Ashraf M Abu-Seida, Tarek M Abdelaziz, Mohamed H Issa, Khaled E El-Haddad

Abstract read
In one paragraph

Article in Open veterinary journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Recent Use of Hyaluronic Acid in Dental Medicine.Materials (Basel, Switzerland) · 2025
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed S AbdelsalamDepartment of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Abeer A ElgendyDepartment of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Ashraf M Abu-SeidaDepartment of Surgery, Anesthesiology & Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Tarek M AbdelazizDepartment of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Mohamed H IssaDepartment of Conservative Dentistry and Endodontics, Faculty of Dentistry, University of Tripoli, Tripoli, Libya.
Khaled E El-HaddadDepartment of Basic Oral Medical Sciences, College of Dentistry, Qassim University, Buraydah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Regenerative endodontics' primary objective is to establish a favorable environment in the root canal by removing infection, providing a sturdy scaffold, and sealing the apical end of the tooth tightly. These actions should promote pulp regeneration and root development. Aim: This study evaluated histologically the regenerative potential of injectable hyaluronic acid (HA) hydrogel or collagen with blood clot as scaffolds during revascularization of immature necrotic dog's teeth. Methods: Sixteen permanent immature necrotic premolars with 32 roots were chosen from two 4-5-month-old mongrel dogs. Out of the 32 roots, 24 roots were sealed for 2 weeks after being cleaned with CaOH Results: When comparing the treated groups to the control group, a significant increase in tissue ingrowth and a significant decrease in the periapical inflammatory reaction were noted ( Conclusion: The tissue regeneration of the immature necrotic teeth is improved by revascularization, whether or not it is combined with HA or collagen scaffolds. After revascularization, using HA as a scaffold is less efficient in reducing the inflammation than collagen.

Indexed as

CollagenHyaluronic AcidAnimalsDental Pulp NecrosisDog DiseasesDogsHydrogelsMaleNeovascularization, PhysiologicRegenerationTissue ScaffoldsCollagenHyaluronic AcidHydrogelsDental pulpsPeriapical pathosisRegenerative endodonticRevascularizationScaffolds

Identifiers

PMID39737041
PMCPMC11682749

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.