Evidence map›Paper›PMID 39736882›Full record

ArticleThe Lancet regional health. Europe2025

Clinical characteristics and serological profiles of Lyme disease in children: a 15-year retrospective cohort study in Switzerland.

Beat M Greiter, Semjon Sidorov, Ester Osuna, Michelle Seiler, Christa Relly, Annette Hackenberg, Isabelle Luchsinger, Elvira Cannizzaro, Roland Martin, Martina Marchesi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Europe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. StreamliningJournal of medical microbiology · 2026
    Observational
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Beat M GreiterDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Semjon SidorovDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Ester OsunaDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Michelle SeilerEmergency Department, University Children's Hospital Zurich, Zurich, Switzerland.
Christa RellyDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Annette HackenbergDepartment of Pediatric Neurology, University Children's Hospital Zurich, Zurich, Switzerland.
Isabelle LuchsingerDepartment of Dermatology, Pediatric Skin Center, University Children's Hospital Zurich, Zurich, Switzerland.
Elvira CannizzaroDepartment of Rheumatology, University Children's Hospital Zurich, Zurich, Switzerland.
Roland MartinInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Martina MarchesiInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Stefanie von FeltenDepartment of Biostatistics at Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland.
Adrian EgliInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Christoph BergerDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Patrick M Meyer SauteurDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lyme disease (LD) is caused by Methods: This retrospective cohort study included children aged 0-18 years, diagnosed with LD according to current guidelines at University Children's Hospital Zurich between January 1, 2006 and December 31, 2020. Two-tier serological testing with the Findings: In total, 469 children diagnosed with LD were included (median age, 7.9 years); 190 patients (40.5%) with Lyme neuroborreliosis (LNB), 171 (36.5%) patients with skin manifestations (erythema migrans, Interpretation: Our study is one of the largest and most detailed for children with LD. We present unique findings regarding the differences in clinical characteristics and immune responses between various manifestations of LD in children. Funding: No specific funding to disclose for this study.

Indexed as

Borrelia burgdorferiErythema migransFacial nerve palsyLyme arthritisMeningitisNeuroborreliosis

Identifiers

PMID39736882
PMCPMC11683244

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.