Evidence map›Paper›PMID 39736855›Full record

ArticleNon-coding RNA research2025

Upregulation of long non-coding RNA ENSG00000267838 is related to the high risk of progression and non-response to chemoradiotherapy treatment for cervical cancer.

Bruna Custódio Dias Duarte, Fábio Ribeiro Queiroz, Álvaro Percínio Costa, Angelo Borges de Melo Neto, Carolina Pereira de Souza Melo, Paulo Guilherme de Oliveira Salles, Wander de Jesus Jeremias, Pedro Luiz Lima Bertarini, Laurence Rodrigues do Amaral, Letícia da Conceição Braga and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Non-coding RNA research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bruna Custódio Dias DuarteLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, 38702-178, Patos de Minas, MG, Brazil.
Fábio Ribeiro QueirozLaboratório de Pesquisa Translacional Em Oncologia, Instituto Mário Penna, 30380-490, Belo Horizonte, MG, Brazil.
Álvaro Percínio CostaPrograma de Pós-graduação Em Ciências Aplicadas à Cirurgia e à Oftalmologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, 31.270-901, Belo Horizonte, MG, Brazil.
Angelo Borges de Melo NetoLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, 38702-178, Patos de Minas, MG, Brazil.
Carolina Pereira de Souza MeloLaboratório de Pesquisa Translacional Em Oncologia, Instituto Mário Penna, 30380-490, Belo Horizonte, MG, Brazil.
Paulo Guilherme de Oliveira SallesLaboratório de Pesquisa Translacional Em Oncologia, Instituto Mário Penna, 30380-490, Belo Horizonte, MG, Brazil.
Wander de Jesus JeremiasLaboratório de Farmacologia Experimental, Escola de Farmácia, Universidade Federal de Ouro Preto, 35402-163, Ouro Preto, MG, Brazil.
Pedro Luiz Lima BertariniLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, 38702-178, Patos de Minas, MG, Brazil.
Laurence Rodrigues do AmaralLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, 38702-178, Patos de Minas, MG, Brazil.
Letícia da Conceição BragaLaboratório de Pesquisa Translacional Em Oncologia, Instituto Mário Penna, 30380-490, Belo Horizonte, MG, Brazil.
Matheus de Souza GomesLaboratório de Bioinformática e Análises Moleculares, Universidade Federal de Uberlândia, 38702-178, Patos de Minas, MG, Brazil.
Agnaldo Lopes da Silva FilhoPrograma de Pós-graduação Em Ciências Aplicadas à Cirurgia e à Oftalmologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, 31.270-901, Belo Horizonte, MG, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer (CC) is a global public health concern, primarily caused by persistent infection with oncogenic types of human papillomavirus (HPV). The World Health Organization (WHO) has established a plan to eliminate CC as a public health issue by the year 2100. However, the implementation of the HPV vaccine is impeded by vaccine restrictions and misinformation despite its demonstrated effectiveness. The CC treatment is influenced by the disease stage, with an unfavorable prognosis for those in advanced stages. This study aimed to investigate the potential of long non-coding RNAs (lncRNAs) in CC by identifying and characterizing related lncRNAs, elucidating their regulatory mechanisms and molecular interactions, and analyzing their expression patterns in patients with diverse responses to chemoradiotherapy. Non-stem cells from CC were isolated using flow cytometry sorting and used for total RNA extraction. The RNA was used to build libraries that were subsequently sequenced using the Illumina Nextseq 550.417 lncRNAs that showed differentially expressed between CC patients who responded or not to treatment. Further analysis demonstrated that these lncRNAs significantly interact with several molecules, which play crucial roles in CC progression and therapeutic resistance. Statistical analysis correlated the expression profile of these lncRNAs with treatment efficacy. Three lncRNAs,

Indexed as

BiomarkersCervical cancerGene expressionNon-coding RNAPrognosisRegulatory profile

Identifiers

PMID39736855
PMCPMC11683307

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.