Evidence map›Paper›PMID 39736733›Full record

ArticleBMC medical informatics and decision making2024

Does the FNA sperm retrieval failure prediction model work well for current NOA individuals undertaking risk screening before the operation? Model validation, high-risk population identification and potential alternative sperm retrieval exploration.

Xiaohui Jiang, Dingming Li, Yi Zheng, Yinxian Li, Hengzhou Bai, Guicheng Zhao, Yi Zhang, Yue Ma

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical informatics and decision making, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Xiaohui Jiang *Human Sperm Bank, West China Second Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.
Dingming LiHuman Sperm Bank, West China Second Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.
Yi Zheng *Human Sperm Bank, West China Second Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.
Yinxian LiChongqing Changshou Women and Children's Hospital, Changshou, Chongqing, China.
Hengzhou BaiHuman Sperm Bank, West China Second Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.
Guicheng ZhaoHuman Sperm Bank, West China Second Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.
Yi ZhangWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yue MaWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. gordonrozen@scu.edu.cn.

Funding

Science and Technology project of the Health Planning Committee of Sichuan 20PJ085Sichuan Science & Technology Program 2021YFS0181
6 · The paper itself

Abstract

backgroundNon-obstructive azoospermia (NOA), the severe type of male infertility. The objective of this study was to evaluate the predictive accuracy of a prediction model of sperm retrieval failure with fine needle aspiration (FNA).

methodsThis study involved 769 NOA patients (dataset 1) undertaking FNA and 140 NOA patients undertaking mTESE (dataset 2). The previous model was validated and then reconstructed for more potential risk factors and better accuracy in dataset 1. The reconstructed model was evaluated in NOA patients with different new variables. The outcomes of the micro- testicular sperm extraction (mTESE) were compared with the predicted outcomes of FNA to evaluate its potential as an alternative surgical sperm retrieval (SSR) technique.

results307 (39.92%) males experienced sperm retrieval failure in FNA while 92 (65.7%) males experienced sperm retrieval failure in mTESE. The refined model has 80% overall agreement (n = 616). The reconstructed model had an AUROC of 0.876 (95% CI: 0.850-0.921). The mTESE has significantly higher success rate (34.29%) than the predicted success rate of FNA (5.71%).

conclusionsPrevious model shows good consistency. mTESE can be an alternative SSR method for NOA patients with a high predicted risk of sperm retrieval failure with FNA.

Indexed as

AzoospermiaSperm RetrievalAdultBiopsy, Fine-NeedleHumansMaleRisk AssessmentFine needle aspiration (FNA)Logistic regressionMicrotesticular sperm extraction (mTESE)Non-obstructive azoospermia (NOA)Sperm retrieval risk prediction

Identifiers

PMID39736733
PMCPMC11686883

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.