Evidence map›Paper›PMID 39736673›Full record

ArticleTrials2024

Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled trial.

Karen J Bosma, Myriam Lafreniere-Roula, Arlene Jiang, Anna Heath, Yongdong Ouyang, Kaitlyn Wade, Pingzhao Hu, Karen E A Burns, Claudio M Martin, Yoanna Skrobik and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02447692 (Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02447692 nacompletednot on this map

Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2016 to 2024Enrolled575ConditionsCritically Ill, Acute Respiratory FailureArmsPSV ventilation strategy, PAV+ ventilation strategy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Karen J Bosma *Division of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Centre Research Institute, London, Canada. KarenJ.Bosma@lhsc.on.ca.ORCID http://orcid.org/0000-0003-0423-7286
Myriam Lafreniere-Roula *Applied Health Research Centre, St. Michael's Hospital, Toronto, Canada.
Arlene JiangChild Health Evaluative Sciences, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.
Anna HeathChild Health Evaluative Sciences, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, and Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Yongdong OuyangChild Health Evaluative Sciences, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, and Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Kaitlyn WadeDepartment of Computer Science, Western University, London, Canada.
Pingzhao HuDepartment of Biochemistry, Schulich School of Medicine & Dentistry and Department of Computer Science, Western University, London, ON, Canada.
Karen E A BurnsInterdepartmental Division of Critical Care, University of Toronto and Division of Critical Care, Unity Health Toronto - St. Michael's Hospital, Toronto, Canada.
Claudio M MartinDivision of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, and London Health Sciences Centre Research Institute, London, Canada.
Yoanna SkrobikDepartment of Medicine, McGill University, Montreal, Canada.
Sorcha MulliganApplied Health Research Centre, St. Michael's Hospital, Toronto, Canada.
Kevin E Thorpe *Dalla Lana School of Public Health, Biostatistics Division, University of Toronto, Toronto, Canada.
Laurent Brochard *Department of Critical Care, Keenan Research Centre, St Michael's Hospital, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
members of the Canadian Critical Care Trials Group and the REVA Network

Funding

CIHR IPR - 136755CIHR PJT - 162086
6 · The paper itself

Abstract

backgroundWe previously published the protocol and statistical analysis plan for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study in Trials ( https://doi.org/10.1186/s13063-023-07163-w ). This update summarizes changes made to the statistical analysis plan for the trial since the publication of the original protocol and statistical analysis plan. METHODS/

designThe Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (PROMIZING) study is a multi-center, open-label, randomized controlled trial designed to determine if ventilation with proportional assist ventilation with load-adjustable gain factors will result in a shorter duration of time spent on mechanical ventilation compared to ventilation with pressure support ventilation for patients with acute respiratory failure. The statistical analysis plan for the trial was incorporated into the original publication of the protocol in Trials ( https://doi.org/10.1186/s13063-023-07163-w ) and was based on version 5.0 of the study protocol and version 1.0 of the statistical analysis plan (SAP), which included plans for both frequentist and Bayesian analyses. We have since updated the SAP to refine the Bayesian analysis plan, update the multistate model diagram, and include plans for a cluster analysis to determine if there is heterogeneity of treatment effect. This update summarizes the changes made and their rationale and provides a refined SAP for the PROMIZING trial with additional background information, in adherence with guidelines for the prospective reporting of SAPs for randomized controlled trials.

trial registrationClinicalTrials.gov Identifier: NCT02447692 prospectively registered May 19, 2015.

Indexed as

Bayes TheoremData Interpretation, StatisticalDuration of TherapyHumansInteractive Ventilatory SupportMulticenter Studies as TopicRandomized Controlled Trials as TopicResearch DesignRespiration, ArtificialRespiratory InsufficiencyTime FactorsTreatment OutcomeBayesianClusterLiberationProportional assist ventilationStatistical analysis planVentilator-free daysWeaning from mechanical ventilation

Identifiers

PMID39736673
PMCPMC11684088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.