Evidence map›Paper›PMID 39736517›Full record

ArticleBMC gastroenterology2024

Fatigue, pain and faecal incontinence in adult inflammatory bowel disease patients and the unmet need: a national cross-sectional survey.

Ailsa Hart, Laura Miller, Fionn Cléirigh Büttner, Thomas Hamborg, Sonia Saxena, Richard C G Pollok, Imogen Stagg, Vari Wileman, Qasim Aziz, Wladyslawa Czuber-Dochan and 5 more

Abstract read
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Article in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ailsa HartSt Mark's Hospital Central Middlesex, Acton Lane, NW10 7NS, London, UK.ORCID http://orcid.org/0000-0002-7141-6076
Laura MillerUnit for Social and Community Psychiatry, Centre for Psychiatry and Mental Health (CPMH), Wolfson Institute of Population Health, Queen Mary University of London, Newham Centre for Mental Health, Glen Road, London, E13 8SP, UK.ORCID http://orcid.org/0000-0001-8802-3554
Fionn Cléirigh BüttnerPragmatic Clinical Trials Unit, Centre for Evaluation and Methods, Wolfson Institute of Population Health, Queen Mary University of London, Yvonne Carter Building, 58 Turner Street, London, E1 2AB, UK.ORCID http://orcid.org/0000-0002-5987-3063
Thomas HamborgPragmatic Clinical Trials Unit, Centre for Evaluation and Methods, Wolfson Institute of Population Health, Queen Mary University of London, Yvonne Carter Building, 58 Turner Street, London, E1 2AB, UK.ORCID http://orcid.org/0000-0001-7154-3983
Sonia SaxenaSchool for Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-3787-2083
Richard C G PollokDept. Gastroenterology, St George's University of London and NHS Trust, St George's Hospital, Blackshaw Road, SW17 0QT, London, UK.ORCID http://orcid.org/0000-0001-6452-6763
Imogen StaggSt Mark's Hospital Central Middlesex, Acton Lane, NW10 7NS, London, UK.ORCID http://orcid.org/0000-0001-9862-5508
Vari WilemanDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Guy's Hospital Campus, 5th floor Bermondsey Wing, SE1 9RT, London Bridge, London, UK.ORCID http://orcid.org/0000-0002-9673-8047
Qasim AzizCentre for Neuroscience, Surgery and Trauma, Wingate Institute and Blizard Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-2718-2065
Wladyslawa Czuber-DochanFlorence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, 57 Waterloo Road, London, London, SE1 8WA, UK.ORCID http://orcid.org/0000-0002-9889-1248
Lesley DibleyInstitute for Lifecourse Development, Faculty of Education, Health and Human Sciences, University of Greenwich, Avery Hill Campus, Avery Hill Road, SE9 2UG, Eltham, London, UK.ORCID http://orcid.org/0000-0001-7964-7672
Borislava MihaylovaHealth Economics and Policy Research Unit, Wolfson Institute of Population Health, Queen Mary University of London, Yvonne Carter Building, 58 Turner Street, London, E1 2AB, UK.ORCID http://orcid.org/0000-0002-0951-1304
Rona Moss-MorrisDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Guy's Hospital Campus, 5th floor Bermondsey Wing, SE1 9RT, London Bridge, London, UK.ORCID http://orcid.org/0000-0002-2927-3446
Chris RoukasHealth Economics and Policy Research Unit, Wolfson Institute of Population Health, Queen Mary University of London, Yvonne Carter Building, 58 Turner Street, London, E1 2AB, UK.ORCID http://orcid.org/0000-0001-8410-7689
Christine NortonFlorence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, 57 Waterloo Road, London, London, SE1 8WA, UK. christine.norton@kcl.ac.uk.ORCID http://orcid.org/0000-0003-2259-0948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe co-existence of fatigue, pain and faecal incontinence in people with Inflammatory Bowel Disease (IBD) is unknown. We aimed to determine the presence of and relationship between these symptoms and patients' desire for intervention.

methodsAdults with IBD in the UK, recruited from clinics, the national IBD-BioResource, a patient charity and social media sources, completed PROMIS validated patient-reported questionnaires to identify fatigue, pain and faecal incontinence, in addition to symptom severity and impact, disease activity, anxiety and depression questionnaires and questions about their desire for help with these symptoms. Statistical analysis used descriptive statistics to report presence of symptoms and Pearson correlation coefficients were calculated.

resultsOf 8486 responses, 54% reported faecal incontinence, 24% reported fatigue, and 21% reported pain; 10% reported all three symptoms in the past 7 days. Only 29% reported none of these symptoms. Fatigue and pain were moderately correlated (Pearson correlation coefficient 0.57); both fatigue and pain had a lower correlation with faecal incontinence (0.43 and 0.46 respectively). On a 0-10 scale for severity, participants scored fatigue highest, followed by incontinence then pain. For impact, participants scored incontinence highest, followed by fatigue then pain. 56% reported depression (27% with clinically relevant levels) and 49% reported anxiety (20% with clinically relevant levels); 23% had previously medically diagnosed mental health disorders. 56% of respondents "definitely" wanted help for fatigue; 53% for incontinence; 42% for pain; 29% "definitely" wanted help with all three symptoms. Factors associated with all three symptoms were Crohn's disease (vs. ulcerative colitis), IBD activity, IBD Control score, anxiety, depression, and history of surgery (all p ≤ 0.0001).

conclusionsFatigue, pain and incontinence are common in IBD and patients desire help for these symptoms, currently a substantial unmet need. Anxiety and depression are common, are underdiagnosed, and are independently associated with these symptoms.

Indexed as

FatigueFecal IncontinenceInflammatory Bowel DiseasesPainAdultAgedAnxietyCross-Sectional StudiesDepressionFemaleHumansMaleMiddle AgedSeverity of Illness IndexSurveys and QuestionnairesUnited KingdomCrohn’s diseaseFaecal incontinenceFatigueInflammatory bowel diseasePainUlcerative colitis

Identifiers

PMID39736517
PMCPMC11686953

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.