Observational studyThe journal of allergy and clinical immunology. In practice2025
Total Serum IgE in a Cohort of Children With Food Allergy.
Observational study in The journal of allergy and clinical immunology. In practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Racial and socioeconomic disparities exist in pediatric food allergy patients pursuing omalizumab.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Non-syndromic hyper-IgE in children: A practical approach.The World Allergy Organization journal · 2026Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundTotal serum IgE (TsIgE) has not been examined in children with food allergy.
objectiveTo evaluate associations of TsIgE with patient, household, environmental, and community-level characteristics among children with food allergy.
methodWe used linear mixed-effects models of data from 398 Black and/or African American (B/AA) and White and/or European American (W/EA) children with allergist-diagnosed food allergy from the multicenter, observational cohort FORWARD (Food Allergy Outcomes Related to White and African American Racial Differences); TsIgE (kU/L) was the primary outcome measure.
resultsIn univariable analyses of data from all study sites, children's TsIgE was positively associated with older age (P < .001); B/AA race (P < .001); male sex (P = .014); lower household income (P = .005); lower caregiver education (P = .005); higher Area Deprivation Index (P < .001); presence of allergic rhinitis (P < .001), asthma (P < .001), and eczema (P = .024); and a higher number of food allergies (P < .001), but not with tobacco smoke exposure. With covariable adjustment in multivariable analysis, total serum IgE was higher in older versus younger children (P < .001), male versus female children, B/AA versus W/EA children (P < .001), and in children with allergic rhinitis (P = .010), asthma (P < .001), eczema (P = .007), or a higher number of food allergies (P < .001), but not with tobacco smoke exposure or Area Deprivation Index.
conclusionsIn children with food allergy, age, sex, race, atopic diagnosis, allergic rhinitis, asthma, and eczema are associated with TsIgE. These findings are important when TsIgE values are used in diagnosis and therapies.
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