Observational studyActa paediatrica (Oslo, Norway : 1992)2025
High-flow nasal cannula oxygen therapy for children with bronchiolitis: Implementation of a national guideline.
Observational study in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High-flow nasal cannula for lower respiratory infections in children under 2 years: a systematic review of indications.Archives of disease in childhood · 2026Pooled it
- High-Flow Nasal Cannula and Continuous Positive Airway Pressure in Infants With Acute Bronchiolitis-Trends of Use in Norway.Acta paediatrica (Oslo, Norway : 1992) · 2026Observational
- Association of high-flow nasal cannula (HFNC) therapy with intensive care unit admission and mechanical ventilation use in respiratory syncytial virus-positive bronchiolitis in pediatric patients: a retrospective single-center cohort study.BMC pulmonary medicine · 2026Article
- High-flow nasal cannula oxygen therapy for children with bronchiolitis: Implementation of a national guideline.Acta paediatrica (Oslo, Norway : 1992) · 2025Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimHigh flow nasal cannula (HFNC) therapy is a form of respiratory support used in children with bronchiolitis. A national guideline for the use of HFNC was published in The Netherlands in 2020. We studied the implementation and use of this guideline.
methodsWe performed a multicentre observational study amongst all hospitals in the North-West part of The Netherlands referring to the same paediatric intensive care unit (PICU). This study consisted of two parts: a comparison of local HFNC protocols to the national guideline and a survey about the use of HFNC amongst paediatricians in the participating centres.
resultsWe observed considerable variations between the local protocols and the national protocol, especially regarding criteria to initiate HFNC treatment and weaning practices. Survey results showed that expectations of HFNC widely varied, while the clinical use of HFNC deviated from both the national guideline as well as local protocols, especially for weaning practices and the use of pCO
conclusionImplementation of the national guideline for HFNC therapy in bronchiolitis was inefficacious, leading to non-uniform clinical practice.
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