ArticleActa paediatrica (Oslo, Norway : 1992)2025
Finnish nationwide controlled register study found increased inpatient infections in children with 22q11.2 deletion syndrome.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Finnish nationwide controlled register study found increased inpatient infections in children with 22q11.2 deletion syndrome.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- From DGCR8 expression analysis to diseased pathways in 22q11.2 deletion syndrome.Frontiers in immunology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
aimStudies on treating infections in children with 22q11.2 deletion syndrome (22q11.2DS) have been limited. We characterised inpatient infections and outpatient antibiotic treatment.
methodsChildren born during 2005-2018 were eligible for this national Finnish retrospective register-based study. We recruited 98 children (54% male) with DiGeorge or velocardiofacial syndrome. The 980 matched controls had a benign murmur diagnosed before 1 year of age. The cumulative incidence of infections and antibiotic prescriptions and total prescriptions were measured.
resultsThe median age for 22q11.2DS diagnoses was under 1 year of age (range 0-14 years), with a median follow-up time of 9 years for diagnoses and 11 years for prescriptions. Children with 22q11.2DS had significantly higher hospitalisation rates than the controls for any infection (68.1% vs. 30.5%), gastroenteritis (16.8% vs. 4.0%), pneumonia (23.4% vs. 4.3%), severe bacterial infections, excluding pneumonia or pyelonephritis (15.0% vs. 4.1%) and viral wheezing (23.2% vs. 9.1%). Outpatient antibiotic prescriptions were similar, but the children with 22q11.2DS received them earlier than the controls, with a hazard ratio of 3.29 for ages 0-5 years and 1.84 for the entire follow-up.
conclusionChildren with 22q11.2DS had significantly more infections requiring hospitalisation than controls without the syndrome.
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