Evidence map›Paper›PMID 39735671›Full record

ReviewOncology research2025

Engendered nanoparticles for treatment of brain tumors.

Soroush Soleymani, Mohammad Doroudian, Mahdieh Soezi, Ali Beladi, Kiarash Asgari, Aso Mobarakshahi, Aryana Aghaeipour, Ronan Macloughlin

Abstract readReview
In one paragraph

Review in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Advances in the application of molecular docking in nanomedicine.Journal of computer-aided molecular design · 2026
    Article
  3. Current trends in exosomes as therapeutic drug delivery systems.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Temperature- and pH-Responsive Poly(NIPAM-Gels (Basel, Switzerland) · 2025
    Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Soroush SoleymaniDepartment of Cell and Molecular Biology, School of Biological Sciences, University of Leicester, Leicester, LE1 7RH, UK.
Mohammad DoroudianDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, 15719-14911, Iran.
Mahdieh SoeziCancer Epidemiology Research Center, Aja University of Medical Sciences, Tehran, 14117-18541, Iran.
Ali BeladiDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, UK.
Kiarash AsgariDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, 15719-14911, Iran.
Aso MobarakshahiDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, 15719-14911, Iran.
Aryana AghaeipourDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, 15719-14911, Iran.
Ronan MacloughlinSchool of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI), Dublin, D02 YN77, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors. Its median survival time is typically less than a year after diagnosis. One of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous system. The blood-brain barrier is cooperating with advanced stages of malignancy. The blood-brain barrier poses a significant challenge to delivering systemic medications to brain tumors. Nanodrug delivery systems have emerged as promising tools for effectively crossing this barrier. Additionally, the development of smart nanoparticles brings new hope for cancer diagnosis and treatment. These nanoparticles improve drug delivery efficiency, allowing for the creation of targeted and stimuli-responsive delivery methods. This review highlights recent advancements in nanoparticle and smart nanoparticle technologies for brain cancer treatment, exploring the range of nanoparticles under development, their applications, targeting strategies, and the latest progress in enhancing transport across the blood-brain barrier. It also addresses the ongoing challenges and potential benefits of these innovative approaches.

Indexed as

Blood-Brain BarrierBrain NeoplasmsDrug Delivery SystemsNanoparticlesAnimalsAntineoplastic AgentsDrug CarriersGlioblastomaHumansNanoparticle Drug Delivery SystemAntineoplastic AgentsDrug CarriersNanoparticle Drug Delivery SystemBlood-brain barrier (BBB)Brain cancerNanoparticlesSmart nanoparticlesStimuli responsive nanoparticlesTargeted nanoparticles

Identifiers

PMID39735671
PMCPMC11671406

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.