Evidence map›Paper›PMID 39735582›Full record

ArticleFrontiers in veterinary science2024

Vaccine sero-monitoring and sero-surveillance of Peste des petits ruminants in small ruminants in West Gojjam zone, Amhara region, Ethiopia.

Mesafint Mandefro, Saddam Mohammed Ibrahim, Demeke Sibhatu, Nebiyou Kassa, Kemal Emiyu, Kebede Debebe, Bereket Dessalegn, Mastewal Birhan, Molalegne Bitew

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Article in Frontiers in veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mesafint MandefroMetema District Livestock and Fishery Resource Development Office, Metema, Ethiopia.
Saddam Mohammed IbrahimCollege of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia.
Demeke SibhatuSerology Laboratory, Animal Health Institute, Sebeta, Ethiopia.
Nebiyou KassaSerology Laboratory, Animal Health Institute, Sebeta, Ethiopia.
Kemal EmiyuSerology Laboratory, Animal Health Institute, Sebeta, Ethiopia.
Kebede DebebeSerology Laboratory, Animal Health Institute, Sebeta, Ethiopia.
Bereket DessalegnCollege of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia.
Mastewal BirhanCollege of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia.
Molalegne BitewDepartment of Health Biotechnology, Bio and Emerging Institute Technology, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Peste des petits ruminants (PPR) is an acute or subacute, highly contagious, and economically important, transboundary disease of small ruminants caused by Peste des petits ruminants virus (PPRV). Objectives: The objective of this study was to determine the seroconversion rate in PPR vaccinated flock of sheep (Sekela district) and the seroprevalence of PPRV in unvaccinated flocks of sheep and goats (Yilmanadensa district). Methods: A cross-sectional study was conducted from January to March 2022 in two selected districts of West Gojjam zone, Ethiopia. Multistage cluster sampling was used to select sampling units by successively selecting districts, kebeles, and villages purposively based on their accessibility and vaccination status. Individual animals were selected haphazardly mimicking simple random sampling. Accordingly, a total of 660 blood samples were collected. Out of this, 300 sheep were vaccinated 4 months prior to sampling using the Nigerian 75/1 strain-based freeze-dried live attenuated PPR vaccine and 360 small ruminants (288 sheep and 72 goats) were unvaccinated and assayed for anti-PPRV antibodies using commercial c-ELISA. Results: The post-vaccination herd immunity was 76.66% (95% CI: 71.46-81.34), which is slightly lower than the threshold herd immunity recommended by the PPR global control and eradication strategy, which is set to be 80%, to efficiently break the epidemiological cycle of the virus. Seroprevalence of PPRV in unvaccinated sheep and goats was 3.61% (95% CI: 1.94-6.1), indicating the possible circulation of PPRV in the area. Although small ruminants develop solid immunity following natural infection in endemic countries, the infection of naïve animals allows continuous circulation of the virus. Conclusions: In light of the accumulating evidence of low post-vaccination herd immunity in small ruminants in Ethiopia, the undergoing PPR vaccination strategy needs to be reevaluated to achieve the desired herd immunity at any time ultimately aiding the eradication goal by 2030.

Indexed as

Amhara National Regional StatePPR eradicationseroconversionseroprevalencesmall ruminantsvaccine monitoring

Identifiers

PMID39735582
PMCPMC11671518

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.