Evidence map›Paper›PMID 39735490›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2024

The serotonergic psychedelic N,N-dipropyltryptamine alters information-processing dynamics in in vitro cortical neural circuits.

Thomas F Varley, Daniel Havert, Leandro Fosque, Abolfazl Alipour, Naruepon Weerawongphrom, Hiroki Naganobori, Lily O'Shea, Maria Pope, John Beggs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. An integratediScience · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas F VarleySchool of Informatics, Computing, and Engineering, Indiana University, Bloomington, IN, USA.ORCID https://orcid.org/0000-0002-3317-9882
Daniel HavertDepartment of Physics, Indiana University, Bloomington, IN, USA.
Leandro FosqueDepartment of Physics, Indiana University, Bloomington, IN, USA.
Abolfazl AlipourDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Naruepon WeerawongphromDepartment of Physics, Indiana University, Bloomington, IN, USA.
Hiroki NaganoboriDepartment of Physics, Indiana University, Bloomington, IN, USA.
Lily O'SheaIndiana University, Bloomington, IN, USA.
Maria PopeSchool of Informatics, Computing, and Engineering, Indiana University, Bloomington, IN, USA.
John BeggsDepartment of Physics, Indiana University, Bloomington, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most of the recent work in psychedelic neuroscience has been done using noninvasive neuroimaging, with data recorded from the brains of adult volunteers under the influence of a variety of drugs. While these data provide holistic insights into the effects of psychedelics on whole-brain dynamics, the effects of psychedelics on the mesoscale dynamics of neuronal circuits remain much less explored. Here, we report the effects of the serotonergic psychedelic N,N-diproptyltryptamine (DPT) on information-processing dynamics in a sample of in vitro organotypic cultures of cortical tissue from postnatal rats. Three hours of spontaneous activity were recorded: an hour of predrug control, an hour of exposure to 10-

Indexed as

ComputationInformation dynamicsInformation theoryNetwork neurosciencePartial information decompositionPsychedelicsSynergyTransfer entropy

Identifiers

PMID39735490
PMCPMC11674936

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.