Evidence map›Paper›PMID 39735335›Full record

ArticleBioactive materials2025

A ceramic microbridge microfluidic chip to study osteogenic differentiation of mesenchymal stem cells in bioactive ceramic immune microenvironment.

Sheng Ye, Quanle Cao, Panxianzhi Ni, Shuting Xiong, Meng Zhong, Tun Yuan, Jing Shan, Jie Liang, Yujiang Fan, Xingdong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Hydrogel-WrappedMaterials today. Bio · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sheng YeCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.
Quanle CaoCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.
Panxianzhi NiCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.
Shuting XiongCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.
Meng ZhongCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.
Tun YuanCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.
Jing ShanDepartment of Gastroenterology, the 3rd People's Hospital of Chengdu, Southwest Jiaotong University, Chengdu, Sichuan, 610064, China.
Jie LiangCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.
Yujiang FanCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.
Xingdong ZhangCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioactive ceramics have been used in bone tissue repair and regeneration. However, because of the complex in vivo osteogenesis process, long cycle, and difficulty of accurately tracking, the mechanism of interaction between materials and cells has yet to be fully understood, hindering its development. The ceramic microbridge microfluidic chip system may solve the problem and provide an in vitro method to simulate the microenvironment in vivo. Nevertheless, the complex microenvironment parameters of the chip system need to be studied in detail. Computer simulation bionics can provide clues for the setting of microenvironment parameters. This study used a computational bionic model to simulate the bone growth process in the presence of immune-related factors. The osteoblast differentiation of mesenchymal stem cells of calcium phosphate ceramics in a macrophage-dominated immune microenvironment was studied using a microfluidic chip system. The computational biomimetic model and microfluidic chip findings were basically consistent with the reported results of the animal experiments. These findings suggest that studying the osteogenic behavior of calcium phosphate ceramics using a microfluidic chip model is feasible. The method model provided in this study can be extended to other biomaterials, providing a viable path for their research and evaluation.

Indexed as

Bioactive ceramicsComputer simulation bionicsImmune microenvironmentResearch and evaluationThe ceramic microbridge microfluidic chip system

Identifiers

PMID39735335
PMCPMC11681893

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.