Evidence map›Paper›PMID 39735334›Full record

ArticleCase reports in transplantation2024

Combined Solid Organ Transplant and Transfusion-Associated Graft-Versus-Host Disease in a Lung Transplant Recipient: An Uncertain Culprit With Lethal Complications.

Devika Sindu, Brian J Franz, Ian Scott, Hashem Ayyad, Kristina Gaines, Kendra McAnally, Sofya Tokman

Abstract readCase Reports
In one paragraph

Article in Case reports in transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Devika SinduNorton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.ORCID https://orcid.org/0000-0002-4420-3622
Brian J FranzHistocompatibility Laboratory, Vitalant, Phoenix, Arizona, USA.
Ian ScottHistocompatibility Laboratory, Vitalant, Phoenix, Arizona, USA.
Hashem AyyadAnatomic Pathology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Kristina GainesHistocompatibility Laboratory, Vitalant, Phoenix, Arizona, USA.
Kendra McAnallyNorton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Sofya TokmanNorton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.ORCID https://orcid.org/0000-0003-2821-8776

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplantation, it is rare after solid organ transplantation (SOT) or blood transfusion. We present a rare case of SOT-derived and/or transfusion-associated graft-versus-host disease (TA-GVHD) in a 66-year-old man with interstitial lung disease who underwent bilateral lung transplantation (LT) from a 12-year-old female donor and required three units of packed red blood cells intraoperatively. He presented with signs and symptoms consistent with GVHD, and a bone marrow biopsy revealed an XX karyotype. He died 3 months after bilateral LT, and postmortem chimerism testing using next-generation sequencing identified three sources of DNA within his bone marrow, including the recipient, the lung donor, and a third donor, thereby suggesting the presence of solid organ transplant graft-versus-host disease (SOT-GVHD), TA-GVHD, or a combination of both.

Indexed as

bone marrowchimerismgraft-versus-host diseaselung transplanttransfusion

Identifiers

PMID39735334
PMCPMC11681980

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.