Evidence map›Paper›PMID 39735267›Full record

Trial reportWorld journal of gastroenterology2024

Efficacy and safety of rebamipide/nizatidine in patients with erosive gastritis: A randomized, multicenter, phase 4 study.

Donghoon Kang, Myung-Gyu Choi, Ki-Nam Shim, Hye-Kyung Jung, Seung-Joo Nam, Jung Ho Park, Sang Gyun Kim, Nam-Hoon Kim, Su Jin Hong, Tae Joo Jeon and 12 more

Abstract readClinical Trial, Phase IVComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Donghoon KangDepartment of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, South Korea.
Myung-Gyu ChoiDepartment of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, South Korea. choim@catholic.ac.kr.
Ki-Nam ShimDepartment of Internal Medicine, Ewha Womans University Seoul Hospital, Gastroenterology and Hepatology Center, Seoul 07985, South Korea.
Hye-Kyung JungDepartment of Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul 07985, South Korea.
Seung-Joo NamDepartment of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 24289, South Korea.
Jung Ho ParkDepartment of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, South Korea.
Sang Gyun KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul 03080, South Korea.
Nam-Hoon KimDepartment of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang 10380, South Korea.
Su Jin HongDepartment of Internal Medicine, Digestive Disease Center, Soonchunhyang University Bucheon Hospital, Bucheon 31538, South Korea.
Tae Joo JeonDepartment of Internal Medicine, Inje University College of Medicine, Sanggye Paik Hospital, Seoul 01757, South Korea.
Jae Il ChungDepartment of Gastroenterology, Sahmyook Medical Center, Seoul 02500, South Korea.
Hang Lak LeeDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul 04763, South Korea.
Ju Yup LeeDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu 42601, South Korea.
Tae Oh KimDepartment of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, South Korea.
Chang Min LeeDepartment of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju 52727, South Korea.
Sun Moon KimDepartment of Internal Medicine, Konyang University Hospital, Daejeon 35365, South Korea.
Jeong-Hwan KimGastroenterology Center, Konkuk University Medical Center, Seoul 05030, South Korea.
Jang Eon KimDepartment of Gastroenterology, Seoul Medical Center, Seoul 02053, South Korea.
Jeong Seop MoonDepartment of Gastroenterology, Inje University Busan Paik Hospital, Busan 47392, South Korea.
Ho Dong KimDepartment of Gastroenterology, St. Carollo Hospital, Sooncheon 57931, South Korea.
Wan-Sik LeeDivision of Gastroenterology, Department of Internal Medicine, Chonnam Medical University Hwasun Hospital, Hwasun 58128, South Korea.
Hong Jun ParkDivision of Gastroenterology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFor the treatment of gastritis, rebamipide, a mucoprotective agent, and nizatidine, a gastric acid suppressant, are commonly employed individually.

aimTo compare the efficacy of Mucotra

methodsA total of 260 patients diagnosed with endoscopically confirmed erosive gastritis were enrolled in this open-label, multicenter, randomized, phase 4 clinical trial, allocating them into two groups: Rebamipide/nizatidine combination twice daily

resultsPrimary efficacy assessment showed a statistically significant improvement rate in mucosal erosions in the combination group compared to the control group in the full-analysis set (rebamipide/nizatidine 62.0%, nizatidine 49.2%,

conclusionRebamipide/nizatidine combination is effective in treatment of erosive gastritis.

Indexed as

AlanineGastritisNizatidineQuinolonesAdultAgedAnti-Ulcer AgentsDrug Therapy, CombinationFemaleGastric MucosaGastroscopyHumansMaleMiddle AgedTreatment OutcomeAlanineAnti-Ulcer AgentsNizatidineQuinolonesrebamipideCombination therapyErosive gastritisGastritisNizatidineRebamipide

Identifiers

PMID39735267
PMCPMC11612702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.