ArticleFrontiers in cellular and infection microbiology2024
Immunoinflammatory markers SIRI and NAR as predictors of respiratory distress syndrome and secondary infections in premature infants.
Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Development and validation of a predictive model for acute respiratory distress syndrome in moderate-to-late preterm infants: a multicenter retrospective study.European journal of pediatrics · 2026Article
- Association between novel indicators for inflammation and metabolism and kidney stones: a cross-sectional analysis of NHANES 2007-2018.BMC urology · 2026Article
- Systemic inflammatory response syndrome in pediatric urinary tract infections associated with urolithiasis: a retrospective study of risk factors, pathogens, and antimicrobial resistance at two tertiary hospitals.BMC infectious diseases · 2026Article
- A risk prediction model based on immune-inflammatory-nutritional indicators for predicting 28-day mortality in sepsis patients with acute respiratory distress syndrome.Frontiers in nutrition · 2026Article
- The predictive value of baseline systemic inflammation response index and systemic immune-inflammation index for the risk of infection within 6 months following initial immunosuppressive treatment in patients with ANCA-associated vasculitis.Frontiers in immunology · 2026Article
- Predictive value of novel nutritional inflammation indexes in IVIG-unresponsive Kawasaki disease: a retrospective study.Frontiers in nutrition · 2025Article
- Accuracy of Systemic Inflammatory Indices in Identifying Neonatal Sepsis in Preterms in a Tertiary Care Hospital in Mangalore.F1000Research · 2025Article
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4 authors.
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Abstract
Background: Premature infants are at high risk for neonatal respiratory distress syndrome (RDS) and secondary infections. This study aims to investigate the association between immunoinflammatory markers-the systemic immune inflammation index (SII), systemic inflammation response index (SIRI), and neutrophil-to-albumin ratio (NAR)-and the risk of developing RDS in premature infants. Methods: A total of 2164 premature infants were enrolled in this retrospective study. The clinical records of these neonates (respiratory tract infections, adverse pregnancy history, placental abnormalities, birth weight, Apgar scores, and immunoinflammatory indices) were collected. Comparisons were made between infants with and without RDS. Logistic regression analysis was used to evaluate the relationship between SII, SIRI, NAR and RDS. Results: Among the cohort, 962 infants developed RDS, while 1202 did not. The RDS group showed higher proportions of mothers with adverse pregnancy history, placental abnormalities, birth weight <2.5 kg, and lower Apgar scores at 1 and 5 minutes (all Conclusion: Adverse pregnancy history, placental abnormalities, low birth weight, elevated SIRI and NAR were associated with increased risk of RDS and secondary infections in premature infants. These findings suggest that SIRI and NAR could serve as useful markers for early identification and management of RDS and its complications in this vulnerable population.
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