ArticleFrontiers in cellular and infection microbiology2024
Alterations of the paired maternal vaginal microbiome and neonatal meconium microbiome in vulvovaginal candidiasis positive pregnant women.
Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Species Distribution ofPathogens (Basel, Switzerland) · 2026Article
- Vaginal Microbiota Dysbiosis and Infections: A Comprehensive Review of Microbial and Therapeutic Perspectives.International journal of women's health · 2026Review
- Evaluation ofFrontiers in microbiology · 2026Article
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7 authors.
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Abstract
Background: Women with vulvovaginal candidiasis (VVC) are known to experience vaginal microbial dysbiosis. However, the dynamic alterations of the vaginal microbiome in pregnant women with VVC and its effect on neonatal gut microbiome remain unclear. This study aims to characterize the vaginal microbiome in pregnant women with VVC and its impact on their offspring's meconium microbiome. Methods: Forty-four pregnant women, including 17 with VVC (VVC group) and 27 healthy controls (HC group), along with their 44 offspring, were enrolled in this study. Maternal vaginal samples were collected during the pre- and post-delivery phases. Meconium samples from their newborns were also obtained. Microbial communities were characterized using 16S rRNA sequencing. Results: The vaginal microbiome of healthy pregnant women was predominantly composed of the genus Conclusion: VVC alters the microbiota of both pregnant women and their neonates at birth, suggesting a form of microbial inheritance. These findings underscore the distinctive characteristics of the vaginal microbiome associated with VVC and its potential impact on the formation of early-life gut microbiome.
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