Evidence map›Paper›PMID 39735237›Full record

ArticleJournal of otology2024

Preliminary study of the role of inner ear proteins in vestibular neuritis.

Rong Wang, Weiwei Han, Li Li, Lulu Li, Xiaoxia Liu, Yunqin Wu, Weinv Fan

Abstract read
In one paragraph

Article in Journal of otology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Blood Biomarkers for the Diagnosis of Peripheral Causes of Vestibular Syndrome: A Systematic Review and Meta-Analysis.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rong WangDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China.
Weiwei HanDepartment of Rehabilitation, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China.
Li LiDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China.
Lulu LiDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China.
Xiaoxia LiuDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China.
Yunqin WuDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China.
Weinv FanDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN. Methods: In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension. Additionally, levels of plasma otoconin-90, and otolin-1 were measured and compared. Results: The plasma concentrations of otoconin-90 and otolin-1 may not be significantly different between patients with VN and healthy controls, nor among patients with BPPV secondary to VN and patients with VN without BPPV. Conclusions: Plasma otoconin-90 and otolin-1 levels may not serve as biomarkers of acute VN episodes or predict BPPV occurrence secondary to VN.

Indexed as

Inner ear proteinOtoconin-90Otolin-1Vestibular neuritis

Identifiers

PMID39735237
PMCPMC11681792

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.