ArticleCureus2024
Perioperative Acute Kidney Injury and Prognosis of Infants With Down Syndrome and Congenital Heart Disease.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The incidence and risk factors associated with severe acute kidney injury and operative mortality in neonates following cardiac surgery: a single-center experience.Pediatric nephrology (Berlin, Germany) · 2026Article
- Risk of acute kidney injury following intravenous iodinated contrast exposure among pediatric population: a narrative review.Pediatric radiology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Children with Down syndrome (DS) often have hypoplastic kidneys and urinary tract malformations that increase their renal dysfunction risk. They also have a higher congenital heart disease (CHD) rate, requiring cardiac surgery during infancy. Renal dysfunction in such patients may be associated with the development of cardiac surgery-associated acute kidney injury (CS-AKI), but this remains unclear. In this study, we compared the incidence, severity, and prognosis of CS-AKI between infants with and without DS complicated by CHD. Methods We retrospectively analyzed 144 consecutive infants with (n=59) and without (n=85) DS who underwent cardiac surgery for CHD between January 2013 and October 2018. The primary endpoint was CS-AKI incidence, and the secondary endpoints were CS-AKI severity and perioperative prognosis. We assessed the severity of CS-AKI using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Results The DS group had significantly smaller kidney size when measured by ultrasound at birth than the non-DS group (
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