Evidence map›Paper›PMID 39734545›Full record

ReviewFundamental research2024

The development of ultrasensitive microcalorimeters for bioanalysis and energy balance monitoring.

Hanliang Zhu, Lan Wang, Jianguo Feng, Pavel Neuzil

Abstract readReview
In one paragraph

Review in Fundamental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Exploring the Frontiers of Cell Temperature Measurement and Thermogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hanliang ZhuSchool of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China.
Lan WangSchool of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China.
Jianguo FengSchool of Microelectronics, Hefei University of Technology, Hefei 230009, China.
Pavel NeuzilSchool of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat generation or consumption is required for all biological processes. Microcalorimetry is an ultrasensitive method to measure heat change for various applications. In this paper, we aimed to review the ultrasensitive microcalorimeter systems and their extensive applications in bioanalysis and energy balance monitoring. We first discussed the basic structure of microcalorimeters, including the closed system and open system, temperature sensing methods, isolation materials, and temperature stabilization. Then, we focused on their applications, such as cell metabolism research, biomolecule interaction measurement, biothermal analysis, and calorimetric detection. Finally, we compared the advantages and disadvantages of commercially available microcalorimeters and their contributions to bioresearch. The development of ultrasensitive microcalorimeters provides the tools for bioanalysis at the single-cell, or even subcellular, level, as well as for precise calorimetric detection.

Indexed as

BioanalysisChip calorimeterEnergy balance monitoringMicrofluidicsThermal analysis

Identifiers

PMID39734545
PMCPMC11670687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.